NELL-1 expression in tumors of cartilage

Jia Shen, Gregory LaChaud, Swati Shrestha, Greg Asatrian, Xinli Zhang, Sarah M. Dry, Chia Soo, Kang Ting, Aaron W. James

Research output: Contribution to journalArticlepeer-review


Background/Aims: NELL-1 is a novel osteochondral differentiation factor protein with increasing usage in tissue engineering. Previously, we reported the expression patterns of NELL-1 in bone-forming skeletal tumors. With increasing interest in the use of NELL-1 protein, we sought to examine the expression of NELL-1 in cartilage-forming tumors. Methods: Immunohistochemical expression was examined in human pathologic specimens. Results: Consistent NELL-1 overexpression across all cartilage-forming tumors was observed. Similar degrees of expression were observed in enchondroma, chondrosarcoma, and chondroblastic osteosarcoma. NELL-1 expression did not significantly vary by tumor grade. Conclusion: In summary, NELL-1 demonstrates reliable and consistent expression across cartilage-forming skeletal tumors.

Original languageEnglish (US)
Pages (from-to)S223-S229
JournalJournal of Orthopaedics
StatePublished - Jul 2 2015
Externally publishedYes


  • Chondroblastic osteosarcoma
  • Chondrosarcoma
  • Enchondroma
  • Nell-1
  • Osteosarcoma

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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