NELL-1 expression in tumors of cartilage

Jia Shen; Gregory LaChaud; Swati Shrestha; Greg Asatrian; Xinli Zhang; Sarah M. Dry; Chia Soo; Kang Ting; Aaron W. James

doi:10.1016/j.jor.2015.10.001

NELL-1 expression in tumors of cartilage

Jia Shen, Gregory LaChaud, Swati Shrestha, Greg Asatrian, Xinli Zhang, Sarah M. Dry, Chia Soo, Kang Ting, Aaron W. James

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background/Aims: NELL-1 is a novel osteochondral differentiation factor protein with increasing usage in tissue engineering. Previously, we reported the expression patterns of NELL-1 in bone-forming skeletal tumors. With increasing interest in the use of NELL-1 protein, we sought to examine the expression of NELL-1 in cartilage-forming tumors. Methods: Immunohistochemical expression was examined in human pathologic specimens. Results: Consistent NELL-1 overexpression across all cartilage-forming tumors was observed. Similar degrees of expression were observed in enchondroma, chondrosarcoma, and chondroblastic osteosarcoma. NELL-1 expression did not significantly vary by tumor grade. Conclusion: In summary, NELL-1 demonstrates reliable and consistent expression across cartilage-forming skeletal tumors.

Original language	English (US)
Pages (from-to)	S223-S229
Journal	Journal of Orthopaedics
Volume	12
DOIs	https://doi.org/10.1016/j.jor.2015.10.001
State	Published - Jul 2 2015
Externally published	Yes

Keywords

Chondroblastic osteosarcoma
Chondrosarcoma
Enchondroma
Nell-1
Osteosarcoma

ASJC Scopus subject areas

Orthopedics and Sports Medicine

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10.1016/j.jor.2015.10.001

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@article{b083c4ac4ec048ffaf1beb5763117f6b,

title = "NELL-1 expression in tumors of cartilage",

abstract = "Background/Aims: NELL-1 is a novel osteochondral differentiation factor protein with increasing usage in tissue engineering. Previously, we reported the expression patterns of NELL-1 in bone-forming skeletal tumors. With increasing interest in the use of NELL-1 protein, we sought to examine the expression of NELL-1 in cartilage-forming tumors. Methods: Immunohistochemical expression was examined in human pathologic specimens. Results: Consistent NELL-1 overexpression across all cartilage-forming tumors was observed. Similar degrees of expression were observed in enchondroma, chondrosarcoma, and chondroblastic osteosarcoma. NELL-1 expression did not significantly vary by tumor grade. Conclusion: In summary, NELL-1 demonstrates reliable and consistent expression across cartilage-forming skeletal tumors.",

keywords = "Chondroblastic osteosarcoma, Chondrosarcoma, Enchondroma, Nell-1, Osteosarcoma",

author = "Jia Shen and Gregory LaChaud and Swati Shrestha and Greg Asatrian and Xinli Zhang and Dry, {Sarah M.} and Chia Soo and Kang Ting and James, {Aaron W.}",

note = "Funding Information: The present work was supported by the UCLA Department of Pathology and Laboratory Medicine, the Translational Research Fund, the UCLA Daljit S. and Elaine Sarkaria Fellowship award, and the Orthopaedic Research and Education Foundation with funding provided by the Musculoskeletal Transplant Foundation . The authors thank the staff of UCLA Translational Pathology Core Laboratory, and A.S. James for their excellent technical assistance. Publisher Copyright: {\textcopyright} 2015 Prof. PK Surendran Memorial Education Foundation. Published by Elsevier B.V. All rights reserved.",

year = "2015",

month = jul,

day = "2",

doi = "10.1016/j.jor.2015.10.001",

language = "English (US)",

volume = "12",

pages = "S223--S229",

journal = "Journal of Orthopaedics",

issn = "0972-978X",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - NELL-1 expression in tumors of cartilage

AU - Shen, Jia

AU - LaChaud, Gregory

AU - Shrestha, Swati

AU - Asatrian, Greg

AU - Zhang, Xinli

AU - Dry, Sarah M.

AU - Soo, Chia

AU - Ting, Kang

AU - James, Aaron W.

N1 - Funding Information: The present work was supported by the UCLA Department of Pathology and Laboratory Medicine, the Translational Research Fund, the UCLA Daljit S. and Elaine Sarkaria Fellowship award, and the Orthopaedic Research and Education Foundation with funding provided by the Musculoskeletal Transplant Foundation . The authors thank the staff of UCLA Translational Pathology Core Laboratory, and A.S. James for their excellent technical assistance. Publisher Copyright: © 2015 Prof. PK Surendran Memorial Education Foundation. Published by Elsevier B.V. All rights reserved.

PY - 2015/7/2

Y1 - 2015/7/2

N2 - Background/Aims: NELL-1 is a novel osteochondral differentiation factor protein with increasing usage in tissue engineering. Previously, we reported the expression patterns of NELL-1 in bone-forming skeletal tumors. With increasing interest in the use of NELL-1 protein, we sought to examine the expression of NELL-1 in cartilage-forming tumors. Methods: Immunohistochemical expression was examined in human pathologic specimens. Results: Consistent NELL-1 overexpression across all cartilage-forming tumors was observed. Similar degrees of expression were observed in enchondroma, chondrosarcoma, and chondroblastic osteosarcoma. NELL-1 expression did not significantly vary by tumor grade. Conclusion: In summary, NELL-1 demonstrates reliable and consistent expression across cartilage-forming skeletal tumors.

AB - Background/Aims: NELL-1 is a novel osteochondral differentiation factor protein with increasing usage in tissue engineering. Previously, we reported the expression patterns of NELL-1 in bone-forming skeletal tumors. With increasing interest in the use of NELL-1 protein, we sought to examine the expression of NELL-1 in cartilage-forming tumors. Methods: Immunohistochemical expression was examined in human pathologic specimens. Results: Consistent NELL-1 overexpression across all cartilage-forming tumors was observed. Similar degrees of expression were observed in enchondroma, chondrosarcoma, and chondroblastic osteosarcoma. NELL-1 expression did not significantly vary by tumor grade. Conclusion: In summary, NELL-1 demonstrates reliable and consistent expression across cartilage-forming skeletal tumors.

KW - Chondroblastic osteosarcoma

KW - Chondrosarcoma

KW - Enchondroma

KW - Nell-1

KW - Osteosarcoma

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U2 - 10.1016/j.jor.2015.10.001

DO - 10.1016/j.jor.2015.10.001

M3 - Article

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AN - SCOPUS:84978318075

SN - 0972-978X

VL - 12

SP - S223-S229

JO - Journal of Orthopaedics

JF - Journal of Orthopaedics

ER -

NELL-1 expression in tumors of cartilage

Abstract

Keywords

ASJC Scopus subject areas

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