Negative signaling in B cells: SHIP Grbs Shc

Susheela Tridandapani; Todd Kelley; Damon Cooney; Madhura Pradhan; K. Mark Coggeshall

doi:10.1016/S0167-5699(97)01112-2

Negative signaling in B cells: SHIP Grbs Shc

Susheela Tridandapani, Todd Kelley, Damon Cooney, Madhura Pradhan, K. Mark Coggeshall

Research output: Contribution to journal › Comment/debate › peer-review

65 Scopus citations

Abstract

Negative signaling in B cells is initiated by co-crosslinking of the antigen receptor and the Fcγ, receptor, resulting in cessation of B-cell signaling events and, in turn, inhibiting B-cell proliferation and antibody secretion. Here, a competitive role is proposed for SHIP in blocking the interaction of ShC with the Grb2-Sos complex of proteins that lead to Ras activation in B cells.

Original language	English (US)
Pages (from-to)	424-427
Number of pages	4
Journal	Immunology Today
Volume	18
Issue number	9
DOIs	https://doi.org/10.1016/S0167-5699(97)01112-2
State	Published - Sep 1997
Externally published	Yes

ASJC Scopus subject areas

Immunology

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title = "Negative signaling in B cells: SHIP Grbs Shc",

abstract = "Negative signaling in B cells is initiated by co-crosslinking of the antigen receptor and the Fcγ, receptor, resulting in cessation of B-cell signaling events and, in turn, inhibiting B-cell proliferation and antibody secretion. Here, a competitive role is proposed for SHIP in blocking the interaction of ShC with the Grb2-Sos complex of proteins that lead to Ras activation in B cells.",

author = "Susheela Tridandapani and Todd Kelley and Damon Cooney and Madhura Pradhan and Coggeshall, {K. Mark}",

year = "1997",

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AU - Tridandapani, Susheela

AU - Kelley, Todd

AU - Cooney, Damon

AU - Pradhan, Madhura

AU - Coggeshall, K. Mark

PY - 1997/9

Y1 - 1997/9

N2 - Negative signaling in B cells is initiated by co-crosslinking of the antigen receptor and the Fcγ, receptor, resulting in cessation of B-cell signaling events and, in turn, inhibiting B-cell proliferation and antibody secretion. Here, a competitive role is proposed for SHIP in blocking the interaction of ShC with the Grb2-Sos complex of proteins that lead to Ras activation in B cells.

AB - Negative signaling in B cells is initiated by co-crosslinking of the antigen receptor and the Fcγ, receptor, resulting in cessation of B-cell signaling events and, in turn, inhibiting B-cell proliferation and antibody secretion. Here, a competitive role is proposed for SHIP in blocking the interaction of ShC with the Grb2-Sos complex of proteins that lead to Ras activation in B cells.

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Negative signaling in B cells: SHIP Grbs Shc

Abstract

ASJC Scopus subject areas

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