Abstract
This data review reports the results of 15 patients who were treated with Vacuum-Assisted Closure® (VAC) negative pressure therapy system in addition to the timed, intermittent delivery of an instilled topical solution for management of their complex, infected wounds. Prospective data for 15 patients treated with negative pressure wound therapy (NPWT)-instillation was recorded and analysed. Primary endpoints were compared to a retrospective control group of 15 patients treated with our institution's standard moist wound-care therapy. Culture-specific systemic antibiotics were prescribed as per specific patient need in both groups. All data were checked for normality of distribution and equality of variance and appropriate parametric and non parametric analyses were conducted. Compared with the standard moist wound-care therapy control group, patients in the NPWT-instillation group required fewer days of treatment (36.5 ± 13.1 versus 9.9 ± 4.3 days, P <0.001), cleared of clinical infection earlier (25.9 ± 6.6 versus 6.0 ± 1.5 days, P <0.001), had wounds close earlier (29.6 ± 6.5 versus 13.2 ± 6.8 days, P <0.001) and had fewer in-hospital stay days (39.2 ± 12.1 versus 14.7 ± 9.2 days, P <0.001). In this pilot study, NPWT instillation showed a significant decrease in the mean time to bioburden reduction, wound closure and hospital discharge compared with traditional wet-to-moist wound care. Outcomes from this study analysis suggest that the use of NPWT instillation may reduce cost and decrease inpatient care requirements for these complex, infected wounds.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 399-413 |
| Number of pages | 15 |
| Journal | International Wound Journal |
| Volume | 5 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 2008 |
| Externally published | Yes |
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Keywords
- Instillation
- Negative pressure wound therapy
- Silver nitrate
- Vacuum-assisted closure therapy
- Wound-care infection
ASJC Scopus subject areas
- Surgery
Cite this
Negative pressure wound therapy with instillation : A pilot study describing a new method for treating infected wounds. / Gabriel, Allen; Shores, Jaimie T; Heinrich, Cherrie; Baqai, Waheed; Kalina, Sharon; Sogioka, Norman; Gupta, Subhas.
In: International Wound Journal, Vol. 5, No. 3, 06.2008, p. 399-413.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Negative pressure wound therapy with instillation
T2 - A pilot study describing a new method for treating infected wounds
AU - Gabriel, Allen
AU - Shores, Jaimie T
AU - Heinrich, Cherrie
AU - Baqai, Waheed
AU - Kalina, Sharon
AU - Sogioka, Norman
AU - Gupta, Subhas
PY - 2008/6
Y1 - 2008/6
N2 - This data review reports the results of 15 patients who were treated with Vacuum-Assisted Closure® (VAC) negative pressure therapy system in addition to the timed, intermittent delivery of an instilled topical solution for management of their complex, infected wounds. Prospective data for 15 patients treated with negative pressure wound therapy (NPWT)-instillation was recorded and analysed. Primary endpoints were compared to a retrospective control group of 15 patients treated with our institution's standard moist wound-care therapy. Culture-specific systemic antibiotics were prescribed as per specific patient need in both groups. All data were checked for normality of distribution and equality of variance and appropriate parametric and non parametric analyses were conducted. Compared with the standard moist wound-care therapy control group, patients in the NPWT-instillation group required fewer days of treatment (36.5 ± 13.1 versus 9.9 ± 4.3 days, P <0.001), cleared of clinical infection earlier (25.9 ± 6.6 versus 6.0 ± 1.5 days, P <0.001), had wounds close earlier (29.6 ± 6.5 versus 13.2 ± 6.8 days, P <0.001) and had fewer in-hospital stay days (39.2 ± 12.1 versus 14.7 ± 9.2 days, P <0.001). In this pilot study, NPWT instillation showed a significant decrease in the mean time to bioburden reduction, wound closure and hospital discharge compared with traditional wet-to-moist wound care. Outcomes from this study analysis suggest that the use of NPWT instillation may reduce cost and decrease inpatient care requirements for these complex, infected wounds.
AB - This data review reports the results of 15 patients who were treated with Vacuum-Assisted Closure® (VAC) negative pressure therapy system in addition to the timed, intermittent delivery of an instilled topical solution for management of their complex, infected wounds. Prospective data for 15 patients treated with negative pressure wound therapy (NPWT)-instillation was recorded and analysed. Primary endpoints were compared to a retrospective control group of 15 patients treated with our institution's standard moist wound-care therapy. Culture-specific systemic antibiotics were prescribed as per specific patient need in both groups. All data were checked for normality of distribution and equality of variance and appropriate parametric and non parametric analyses were conducted. Compared with the standard moist wound-care therapy control group, patients in the NPWT-instillation group required fewer days of treatment (36.5 ± 13.1 versus 9.9 ± 4.3 days, P <0.001), cleared of clinical infection earlier (25.9 ± 6.6 versus 6.0 ± 1.5 days, P <0.001), had wounds close earlier (29.6 ± 6.5 versus 13.2 ± 6.8 days, P <0.001) and had fewer in-hospital stay days (39.2 ± 12.1 versus 14.7 ± 9.2 days, P <0.001). In this pilot study, NPWT instillation showed a significant decrease in the mean time to bioburden reduction, wound closure and hospital discharge compared with traditional wet-to-moist wound care. Outcomes from this study analysis suggest that the use of NPWT instillation may reduce cost and decrease inpatient care requirements for these complex, infected wounds.
KW - Instillation
KW - Negative pressure wound therapy
KW - Silver nitrate
KW - Vacuum-assisted closure therapy
KW - Wound-care infection
UR - http://www.scopus.com/inward/record.url?scp=45749134559&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=45749134559&partnerID=8YFLogxK
U2 - 10.1111/j.1742-481X.2007.00423.x
DO - 10.1111/j.1742-481X.2007.00423.x
M3 - Article
C2 - 18593390
AN - SCOPUS:45749134559
VL - 5
SP - 399
EP - 413
JO - International Wound Journal
JF - International Wound Journal
SN - 1742-4801
IS - 3
ER -