Abstract
Motor learning is essential to maintain accurate behavioral responses. We used a larval zebrafish model to study ocular motor learning behaviors. During a sustained period of optokinetic stimulation in 5-day-old wild-type zebrafish larvae the slow-phase eye velocity decreased over time. Then interestingly, a long-lasting and robust negative optokinetic afternystagmus (OKAN) was evoked upon light extinction. The slow-phase velocity, the quick-phase frequency, and the decay time constant of the negative OKAN were dependent on the stimulus duration and the adaptation to the preceding optokinetic stimulation. Based on these results, we propose a sensory adaptation process during continued optokinetic stimulation, which, when the stimulus is removed, leads to a negative OKAN as the result of a changed retinal slip velocity set point, and thus, a sensorimotor memory. The pronounced negative OKAN in larval zebrafish not only provides a practical solution to the hitherto unsolved problems of observing negative OKAN, but also, and most importantly, can be readily applied as a powerful model for studying sensorimotor learning and memory in vertebrates.
| Original language | English (US) |
|---|---|
| Article number | 19039 |
| Journal | Scientific reports |
| Volume | 9 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 1 2019 |
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Negative optokinetic afternystagmus in larval zebrafish demonstrates set-point adaptation. / Lin, Ting Feng; Mohammadi, Mohammad; Fathalla, Ahmed M.; Pul, Duygu; Lüthi, Dennis; Romano, Fausto; Straumann, Dominik; Cullen, Kathleen E.; Chacron, Maurice J.; Huang, Melody Ying Yu.
In: Scientific reports, Vol. 9, No. 1, 19039, 01.12.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Negative optokinetic afternystagmus in larval zebrafish demonstrates set-point adaptation
AU - Lin, Ting Feng
AU - Mohammadi, Mohammad
AU - Fathalla, Ahmed M.
AU - Pul, Duygu
AU - Lüthi, Dennis
AU - Romano, Fausto
AU - Straumann, Dominik
AU - Cullen, Kathleen E.
AU - Chacron, Maurice J.
AU - Huang, Melody Ying Yu
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Motor learning is essential to maintain accurate behavioral responses. We used a larval zebrafish model to study ocular motor learning behaviors. During a sustained period of optokinetic stimulation in 5-day-old wild-type zebrafish larvae the slow-phase eye velocity decreased over time. Then interestingly, a long-lasting and robust negative optokinetic afternystagmus (OKAN) was evoked upon light extinction. The slow-phase velocity, the quick-phase frequency, and the decay time constant of the negative OKAN were dependent on the stimulus duration and the adaptation to the preceding optokinetic stimulation. Based on these results, we propose a sensory adaptation process during continued optokinetic stimulation, which, when the stimulus is removed, leads to a negative OKAN as the result of a changed retinal slip velocity set point, and thus, a sensorimotor memory. The pronounced negative OKAN in larval zebrafish not only provides a practical solution to the hitherto unsolved problems of observing negative OKAN, but also, and most importantly, can be readily applied as a powerful model for studying sensorimotor learning and memory in vertebrates.
AB - Motor learning is essential to maintain accurate behavioral responses. We used a larval zebrafish model to study ocular motor learning behaviors. During a sustained period of optokinetic stimulation in 5-day-old wild-type zebrafish larvae the slow-phase eye velocity decreased over time. Then interestingly, a long-lasting and robust negative optokinetic afternystagmus (OKAN) was evoked upon light extinction. The slow-phase velocity, the quick-phase frequency, and the decay time constant of the negative OKAN were dependent on the stimulus duration and the adaptation to the preceding optokinetic stimulation. Based on these results, we propose a sensory adaptation process during continued optokinetic stimulation, which, when the stimulus is removed, leads to a negative OKAN as the result of a changed retinal slip velocity set point, and thus, a sensorimotor memory. The pronounced negative OKAN in larval zebrafish not only provides a practical solution to the hitherto unsolved problems of observing negative OKAN, but also, and most importantly, can be readily applied as a powerful model for studying sensorimotor learning and memory in vertebrates.
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UR - http://www.scopus.com/inward/citedby.url?scp=85076550766&partnerID=8YFLogxK
U2 - 10.1038/s41598-019-55457-4
DO - 10.1038/s41598-019-55457-4
M3 - Article
C2 - 31836778
AN - SCOPUS:85076550766
VL - 9
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 19039
ER -