Negative impact of 'old-to-old' donations on success of cadaveric renal transplants

Inbal Weiss-Salz, Micha Mandel, Noya Galai, Geoffrey Boner, Eytan Mor, Richard Nakache, Elisheva Simchen, Tamar Ashkenazi, Ahmed Eid, Jonathan Halevi, Aaron Hoffman, Ron Loewenthal, Solly Mizrahi, Ruth Rahamimov, Anat Rotem, Moshe Shabtai

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of 'old-to-old' cadaveric renal transplants on operative complications and graft survival was assessed in all 325 patients undergoing solitary cadaveric renal transplantations in Israel during a 3-yr period. Preoperative information and hospital course data were abstracted from the charts. Results were analyzed using Kaplan-Meyer survival curves, univariate and multivariate Cox models. Overall, 62 (19.1%) grafts failed within a year. Failure rate was 46.2% for 'old-to-old' transplants compared with 15.5% for all other donor/recipient age combinations (p < 0.0001). 'Old-to-old' transplants remained independently associated with graft failure in a multivariate Cox model after controlling the effect of other risk factors. 'Old-to-old' transplants were also associated with increased operative complications relative to other age combinations. The decision to use 'old-to-old' transplants, even when donors are scarce, is problematic and should be reconsidered.

Original languageEnglish (US)
Pages (from-to)372-376
Number of pages5
JournalClinical Transplantation
Volume19
Issue number3
DOIs
StatePublished - Jun 1 2005

Keywords

  • 'Old-to-old' transplants
  • Cadaveric kidney transplant
  • Graft failure
  • Operative complications

ASJC Scopus subject areas

  • Transplantation

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