Negative chronotropic factor in patients with fungemia

B. A. Rosenfeld; Z. J. Bosnjak; R. M. Shapiro; T. Dorman; B. Ligier; M. J. Breslow

doi:10.1097/00003246-199203000-00006

Negative chronotropic factor in patients with fungemia

B. A. Rosenfeld, Z. J. Bosnjak, R. M. Shapiro, T. Dorman, B. Ligier, M. J. Breslow

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Objective: To study the effect of serum from patients with fungemia and control patients on sinoatrial node function. Design: Prospective, observational study. Setting: Surgical ICU in a university hospital. Patients: Fourteen patients with fungemia and 14 control patients. Measurements and Main Results: Serum samples from all patients were assayed in an in vitro sinus node preparation. Serum samples from 11 (78%) of the 14 fungemic patients caused a decrease in sinus node activity, while serum samples from only one (7%) of 14 control patients caused slowing of the sinus node. Conclusions: Serum from many patients with fungemia causes slowing of an in vitro sinus node preparation. This in vitro finding may explain bradyarrhythmias seen clinically in the setting of fungemia.

Original language	English (US)
Pages (from-to)	327-331
Number of pages	5
Journal	Critical care medicine
Volume	20
Issue number	3
DOIs	https://doi.org/10.1097/00003246-199203000-00006
State	Published - Jan 1 1992

Keywords

Gram-negative bacteria
Gram-positive bacteria
action potential
arrhythmia
bacteremia
blood gas analysis
bradycardia
electrocardiography
sinoatrial node

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine

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10.1097/00003246-199203000-00006

Cite this

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title = "Negative chronotropic factor in patients with fungemia",

abstract = "Objective: To study the effect of serum from patients with fungemia and control patients on sinoatrial node function. Design: Prospective, observational study. Setting: Surgical ICU in a university hospital. Patients: Fourteen patients with fungemia and 14 control patients. Measurements and Main Results: Serum samples from all patients were assayed in an in vitro sinus node preparation. Serum samples from 11 (78%) of the 14 fungemic patients caused a decrease in sinus node activity, while serum samples from only one (7%) of 14 control patients caused slowing of the sinus node. Conclusions: Serum from many patients with fungemia causes slowing of an in vitro sinus node preparation. This in vitro finding may explain bradyarrhythmias seen clinically in the setting of fungemia.",

keywords = "Gram-negative bacteria, Gram-positive bacteria, action potential, arrhythmia, bacteremia, blood gas analysis, bradycardia, electrocardiography, sinoatrial node",

author = "Rosenfeld, {B. A.} and Bosnjak, {Z. J.} and Shapiro, {R. M.} and T. Dorman and B. Ligier and Breslow, {M. J.}",

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T1 - Negative chronotropic factor in patients with fungemia

AU - Rosenfeld, B. A.

AU - Bosnjak, Z. J.

AU - Shapiro, R. M.

AU - Dorman, T.

AU - Ligier, B.

AU - Breslow, M. J.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Objective: To study the effect of serum from patients with fungemia and control patients on sinoatrial node function. Design: Prospective, observational study. Setting: Surgical ICU in a university hospital. Patients: Fourteen patients with fungemia and 14 control patients. Measurements and Main Results: Serum samples from all patients were assayed in an in vitro sinus node preparation. Serum samples from 11 (78%) of the 14 fungemic patients caused a decrease in sinus node activity, while serum samples from only one (7%) of 14 control patients caused slowing of the sinus node. Conclusions: Serum from many patients with fungemia causes slowing of an in vitro sinus node preparation. This in vitro finding may explain bradyarrhythmias seen clinically in the setting of fungemia.

AB - Objective: To study the effect of serum from patients with fungemia and control patients on sinoatrial node function. Design: Prospective, observational study. Setting: Surgical ICU in a university hospital. Patients: Fourteen patients with fungemia and 14 control patients. Measurements and Main Results: Serum samples from all patients were assayed in an in vitro sinus node preparation. Serum samples from 11 (78%) of the 14 fungemic patients caused a decrease in sinus node activity, while serum samples from only one (7%) of 14 control patients caused slowing of the sinus node. Conclusions: Serum from many patients with fungemia causes slowing of an in vitro sinus node preparation. This in vitro finding may explain bradyarrhythmias seen clinically in the setting of fungemia.

KW - Gram-negative bacteria

KW - Gram-positive bacteria

KW - action potential

KW - arrhythmia

KW - bacteremia

KW - blood gas analysis

KW - bradycardia

KW - electrocardiography

KW - sinoatrial node

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Negative chronotropic factor in patients with fungemia

Abstract

Keywords

ASJC Scopus subject areas

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