Needles in haystacks: Identifying specific peptide antigens for T cells

Nilabh Shastri

doi:10.1016/S0952-7915(96)80067-7

Needles in haystacks: Identifying specific peptide antigens for T cells

Nilabh Shastri

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The antigen receptors of T cells are engaged by unique peptides displayed by MHC molecules on the antigen-presenting cell surface. These rare peptides can now be distinguished among the thousands normally bound to MHC molecules. Knowledge of the antigenic peptides and their donor proteins is suggesting potential targets for immunotherapy and providing insights into the cellular mechanisms that generate the peptide-MHC complexes.

Original language	English (US)
Pages (from-to)	271-277
Number of pages	7
Journal	Current Opinion in Immunology
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/S0952-7915(96)80067-7
State	Published - Apr 1996
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1016/S0952-7915(96)80067-7

Cite this

@article{3424c6cc3a394c3bb763e24ffa9ad760,

title = "Needles in haystacks: Identifying specific peptide antigens for T cells",

abstract = "The antigen receptors of T cells are engaged by unique peptides displayed by MHC molecules on the antigen-presenting cell surface. These rare peptides can now be distinguished among the thousands normally bound to MHC molecules. Knowledge of the antigenic peptides and their donor proteins is suggesting potential targets for immunotherapy and providing insights into the cellular mechanisms that generate the peptide-MHC complexes.",

author = "Nilabh Shastri",

note = "Funding Information: I thank past and present members of my laboratory for stimulating discussions and for their enthusiastic and successful searches of the antigenic haystacks. I also thank JP Allison and VH Engelhard for discussions and for sharing results before publication. Research in the author's laboratory is funded by grants from the National Institute of Health and the UC Tobacco Disease Related Research Program. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "1996",

month = apr,

doi = "10.1016/S0952-7915(96)80067-7",

language = "English (US)",

volume = "8",

pages = "271--277",

journal = "Current Opinion in Immunology",

issn = "0952-7915",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Needles in haystacks

T2 - Identifying specific peptide antigens for T cells

AU - Shastri, Nilabh

N1 - Funding Information: I thank past and present members of my laboratory for stimulating discussions and for their enthusiastic and successful searches of the antigenic haystacks. I also thank JP Allison and VH Engelhard for discussions and for sharing results before publication. Research in the author's laboratory is funded by grants from the National Institute of Health and the UC Tobacco Disease Related Research Program. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 1996/4

Y1 - 1996/4

N2 - The antigen receptors of T cells are engaged by unique peptides displayed by MHC molecules on the antigen-presenting cell surface. These rare peptides can now be distinguished among the thousands normally bound to MHC molecules. Knowledge of the antigenic peptides and their donor proteins is suggesting potential targets for immunotherapy and providing insights into the cellular mechanisms that generate the peptide-MHC complexes.

AB - The antigen receptors of T cells are engaged by unique peptides displayed by MHC molecules on the antigen-presenting cell surface. These rare peptides can now be distinguished among the thousands normally bound to MHC molecules. Knowledge of the antigenic peptides and their donor proteins is suggesting potential targets for immunotherapy and providing insights into the cellular mechanisms that generate the peptide-MHC complexes.

UR - http://www.scopus.com/inward/record.url?scp=0029888847&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029888847&partnerID=8YFLogxK

U2 - 10.1016/S0952-7915(96)80067-7

DO - 10.1016/S0952-7915(96)80067-7

M3 - Article

C2 - 8725951

AN - SCOPUS:0029888847

SN - 0952-7915

VL - 8

SP - 271

EP - 277

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

IS - 2

ER -

Needles in haystacks: Identifying specific peptide antigens for T cells

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this