Necrotizing infundibulo-hypophysitis: An entity too rare to be true?

Angelika Gutenberg, Patrizio Caturegli, Imke Metz, Ramon Martinez, Alexander Mohr, Wolfgang Brück, Veit Rohde

Research output: Contribution to journalArticlepeer-review


We report a young woman with sudden and severe retroorbital headache, neck pain, and a large sellar mass extending to the suprasellar cistern. A presumptive diagnosis of non-secreting pituitary macroadenoma undergoing apoplexy was made and transphenoidal surgery performed. Histopathology revealed mononuclear infiltration and marked non-hemorrhagic necrosis of the anterior pituitary consistent with a diagnosis of necrotizing infundibulohypophysitis. The possible pathogenesis of this rare variant of hypophysitis is discussed.

Original languageEnglish (US)
Pages (from-to)202-208
Number of pages7
Issue number2
StatePublished - Jun 2012


  • Hypophysitis
  • Necrosis
  • Pituitary infarction

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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