Necrotizing infundibulo-hypophysitis: An entity too rare to be true?

Angelika Gutenberg; Patrizio Caturegli; Imke Metz; Ramon Martinez; Alexander Mohr; Wolfgang Brück; Veit Rohde

doi:10.1007/s11102-011-0307-2

Necrotizing infundibulo-hypophysitis: An entity too rare to be true?

Angelika Gutenberg, Patrizio Caturegli, Imke Metz, Ramon Martinez, Alexander Mohr, Wolfgang Brück, Veit Rohde

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We report a young woman with sudden and severe retroorbital headache, neck pain, and a large sellar mass extending to the suprasellar cistern. A presumptive diagnosis of non-secreting pituitary macroadenoma undergoing apoplexy was made and transphenoidal surgery performed. Histopathology revealed mononuclear infiltration and marked non-hemorrhagic necrosis of the anterior pituitary consistent with a diagnosis of necrotizing infundibulohypophysitis. The possible pathogenesis of this rare variant of hypophysitis is discussed.

Original language	English (US)
Pages (from-to)	202-208
Number of pages	7
Journal	Pituitary
Volume	15
Issue number	2
DOIs	https://doi.org/10.1007/s11102-011-0307-2
State	Published - Jun 2012

Keywords

Hypophysitis
Necrosis
Pituitary infarction

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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title = "Necrotizing infundibulo-hypophysitis: An entity too rare to be true?",

abstract = "We report a young woman with sudden and severe retroorbital headache, neck pain, and a large sellar mass extending to the suprasellar cistern. A presumptive diagnosis of non-secreting pituitary macroadenoma undergoing apoplexy was made and transphenoidal surgery performed. Histopathology revealed mononuclear infiltration and marked non-hemorrhagic necrosis of the anterior pituitary consistent with a diagnosis of necrotizing infundibulohypophysitis. The possible pathogenesis of this rare variant of hypophysitis is discussed.",

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author = "Angelika Gutenberg and Patrizio Caturegli and Imke Metz and Ramon Martinez and Alexander Mohr and Wolfgang Br{\"u}ck and Veit Rohde",

note = "Funding Information: Acknowledgments The work was supported in part by a Heidenreich-von-Siebold grant (Georg-August-University G{\"o}ttingen) to AG. PC was supported in part by NIH grant DK 080351. Copyright: Copyright 2013 Elsevier B.V., All rights reserved.",

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language = "English (US)",

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T2 - An entity too rare to be true?

AU - Gutenberg, Angelika

AU - Caturegli, Patrizio

AU - Metz, Imke

AU - Martinez, Ramon

AU - Mohr, Alexander

AU - Brück, Wolfgang

AU - Rohde, Veit

N1 - Funding Information: Acknowledgments The work was supported in part by a Heidenreich-von-Siebold grant (Georg-August-University Göttingen) to AG. PC was supported in part by NIH grant DK 080351. Copyright: Copyright 2013 Elsevier B.V., All rights reserved.

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N2 - We report a young woman with sudden and severe retroorbital headache, neck pain, and a large sellar mass extending to the suprasellar cistern. A presumptive diagnosis of non-secreting pituitary macroadenoma undergoing apoplexy was made and transphenoidal surgery performed. Histopathology revealed mononuclear infiltration and marked non-hemorrhagic necrosis of the anterior pituitary consistent with a diagnosis of necrotizing infundibulohypophysitis. The possible pathogenesis of this rare variant of hypophysitis is discussed.

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