Neck circumference is not associated with subclinical atherosclerosis in retired national football league players

Yashashwi Pokharel, Francisco Y. Macedo, Vijay Nambi, Seth Martin, Khurram Nasir, Nathan D. Wong, Jeffrey Boone, Arthur J. Roberts, Christie M. Ballantyne, Salim S. Virani

Research output: Contribution to journalArticle

Abstract

Background Neck circumference (NC) is associated with metabolic syndrome (MetS) in the general population. It is not known if NC is associated with MetS and subclinical atherosclerosis in retired National Football League (NFL) players. Hypothesis We hypothesized that NC is associated with MetS and subclinical atherosclerosis (assessed as coronary artery calcium [CAC] and carotid artery plaque [CAP]) in retired NFL players. Methods NC was measured midway between the midcervical spine and midanterior neck in 845 retired NFL players. CAC presence was defined as total CAC score >0. CAP was defined as carotid plaque of at least 50% greater than that of the surrounding vessel wall, with a minimal thickness of at least 1.2 mm on carotid ultrasound. Logistic regression analysis was used for the association of NC with CAC or CAP. Results Of the participants, 21% had MetS. CAC and CAP were present in 62% and 56%, respectively. Those with MetS had a higher median NC than those without MetS (17 vs 16 inches, P <0.0001). NC was not associated with the presence of CAC or CAP in an unadjusted model and after adjusting for age, race, and cardiometabolic risk factors (odds ratio [OR]: 1.11, 95% confidence interval [CI]: 0.94-1.31 for CAC; OR: 0.96, 95% CI: 0.82-1.12 for CAP per 1-standard deviation increase in NC [3.8 inches]). The results were similar when the predictor variable was NC indexed to body mass index. Conclusions In retired NFL players with a high prevalence of CAC and CAP, NC was not associated with coronary or carotid subclinical atherosclerosis. NC may not be the most appropriate risk marker for atherosclerosis.

Original languageEnglish (US)
Pages (from-to)402-407
Number of pages6
JournalClinical Cardiology
Volume37
Issue number7
DOIs
StatePublished - 2014

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Football
Atherosclerosis
Neck
Carotid Stenosis
Coronary Vessels
Calcium
Odds Ratio
Confidence Intervals
Carotid Artery Diseases
Spine
Body Mass Index
Logistic Models
Regression Analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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Neck circumference is not associated with subclinical atherosclerosis in retired national football league players. / Pokharel, Yashashwi; Macedo, Francisco Y.; Nambi, Vijay; Martin, Seth; Nasir, Khurram; Wong, Nathan D.; Boone, Jeffrey; Roberts, Arthur J.; Ballantyne, Christie M.; Virani, Salim S.

In: Clinical Cardiology, Vol. 37, No. 7, 2014, p. 402-407.

Research output: Contribution to journalArticle

Pokharel, Y, Macedo, FY, Nambi, V, Martin, S, Nasir, K, Wong, ND, Boone, J, Roberts, AJ, Ballantyne, CM & Virani, SS 2014, 'Neck circumference is not associated with subclinical atherosclerosis in retired national football league players', Clinical Cardiology, vol. 37, no. 7, pp. 402-407. https://doi.org/10.1002/clc.22270
Pokharel, Yashashwi ; Macedo, Francisco Y. ; Nambi, Vijay ; Martin, Seth ; Nasir, Khurram ; Wong, Nathan D. ; Boone, Jeffrey ; Roberts, Arthur J. ; Ballantyne, Christie M. ; Virani, Salim S. / Neck circumference is not associated with subclinical atherosclerosis in retired national football league players. In: Clinical Cardiology. 2014 ; Vol. 37, No. 7. pp. 402-407.
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abstract = "Background Neck circumference (NC) is associated with metabolic syndrome (MetS) in the general population. It is not known if NC is associated with MetS and subclinical atherosclerosis in retired National Football League (NFL) players. Hypothesis We hypothesized that NC is associated with MetS and subclinical atherosclerosis (assessed as coronary artery calcium [CAC] and carotid artery plaque [CAP]) in retired NFL players. Methods NC was measured midway between the midcervical spine and midanterior neck in 845 retired NFL players. CAC presence was defined as total CAC score >0. CAP was defined as carotid plaque of at least 50{\%} greater than that of the surrounding vessel wall, with a minimal thickness of at least 1.2 mm on carotid ultrasound. Logistic regression analysis was used for the association of NC with CAC or CAP. Results Of the participants, 21{\%} had MetS. CAC and CAP were present in 62{\%} and 56{\%}, respectively. Those with MetS had a higher median NC than those without MetS (17 vs 16 inches, P <0.0001). NC was not associated with the presence of CAC or CAP in an unadjusted model and after adjusting for age, race, and cardiometabolic risk factors (odds ratio [OR]: 1.11, 95{\%} confidence interval [CI]: 0.94-1.31 for CAC; OR: 0.96, 95{\%} CI: 0.82-1.12 for CAP per 1-standard deviation increase in NC [3.8 inches]). The results were similar when the predictor variable was NC indexed to body mass index. Conclusions In retired NFL players with a high prevalence of CAC and CAP, NC was not associated with coronary or carotid subclinical atherosclerosis. NC may not be the most appropriate risk marker for atherosclerosis.",
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T1 - Neck circumference is not associated with subclinical atherosclerosis in retired national football league players

AU - Pokharel, Yashashwi

AU - Macedo, Francisco Y.

AU - Nambi, Vijay

AU - Martin, Seth

AU - Nasir, Khurram

AU - Wong, Nathan D.

AU - Boone, Jeffrey

AU - Roberts, Arthur J.

AU - Ballantyne, Christie M.

AU - Virani, Salim S.

PY - 2014

Y1 - 2014

N2 - Background Neck circumference (NC) is associated with metabolic syndrome (MetS) in the general population. It is not known if NC is associated with MetS and subclinical atherosclerosis in retired National Football League (NFL) players. Hypothesis We hypothesized that NC is associated with MetS and subclinical atherosclerosis (assessed as coronary artery calcium [CAC] and carotid artery plaque [CAP]) in retired NFL players. Methods NC was measured midway between the midcervical spine and midanterior neck in 845 retired NFL players. CAC presence was defined as total CAC score >0. CAP was defined as carotid plaque of at least 50% greater than that of the surrounding vessel wall, with a minimal thickness of at least 1.2 mm on carotid ultrasound. Logistic regression analysis was used for the association of NC with CAC or CAP. Results Of the participants, 21% had MetS. CAC and CAP were present in 62% and 56%, respectively. Those with MetS had a higher median NC than those without MetS (17 vs 16 inches, P <0.0001). NC was not associated with the presence of CAC or CAP in an unadjusted model and after adjusting for age, race, and cardiometabolic risk factors (odds ratio [OR]: 1.11, 95% confidence interval [CI]: 0.94-1.31 for CAC; OR: 0.96, 95% CI: 0.82-1.12 for CAP per 1-standard deviation increase in NC [3.8 inches]). The results were similar when the predictor variable was NC indexed to body mass index. Conclusions In retired NFL players with a high prevalence of CAC and CAP, NC was not associated with coronary or carotid subclinical atherosclerosis. NC may not be the most appropriate risk marker for atherosclerosis.

AB - Background Neck circumference (NC) is associated with metabolic syndrome (MetS) in the general population. It is not known if NC is associated with MetS and subclinical atherosclerosis in retired National Football League (NFL) players. Hypothesis We hypothesized that NC is associated with MetS and subclinical atherosclerosis (assessed as coronary artery calcium [CAC] and carotid artery plaque [CAP]) in retired NFL players. Methods NC was measured midway between the midcervical spine and midanterior neck in 845 retired NFL players. CAC presence was defined as total CAC score >0. CAP was defined as carotid plaque of at least 50% greater than that of the surrounding vessel wall, with a minimal thickness of at least 1.2 mm on carotid ultrasound. Logistic regression analysis was used for the association of NC with CAC or CAP. Results Of the participants, 21% had MetS. CAC and CAP were present in 62% and 56%, respectively. Those with MetS had a higher median NC than those without MetS (17 vs 16 inches, P <0.0001). NC was not associated with the presence of CAC or CAP in an unadjusted model and after adjusting for age, race, and cardiometabolic risk factors (odds ratio [OR]: 1.11, 95% confidence interval [CI]: 0.94-1.31 for CAC; OR: 0.96, 95% CI: 0.82-1.12 for CAP per 1-standard deviation increase in NC [3.8 inches]). The results were similar when the predictor variable was NC indexed to body mass index. Conclusions In retired NFL players with a high prevalence of CAC and CAP, NC was not associated with coronary or carotid subclinical atherosclerosis. NC may not be the most appropriate risk marker for atherosclerosis.

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