Nebulized Furosemide for the Management of Dyspnea: Does the Evidence Support Its Use?

Phillip J. Newton, Patricia M. Davidson, Peter Macdonald, Richard Ollerton, Henry Krum

Research output: Contribution to journalReview articlepeer-review

Abstract

Dyspnea is a common and distressing symptom associated with multiple chronic illnesses and high levels of burden for individuals, their families and health care systems. The subjective nature dyspnea and a poor understanding of pathophysiological mechanisms challenge the clinician in developing management plans. Nebulized furosemide has been identified as a novel approach to dyspnea management. This review summarizes published studies, both clinical and experimental, reporting the use of nebulized furosemide. The search criteria yielded 42 articles published in the period 1988 to 2004. Although nebulized furosemide appeared to have a positive influence on dyspnea and physiological measurements, caution must be taken with the results primarily coming from small-scale clinical trials or observation trials. Despite the limitations of the studies reported, given the range of conditions reporting effectiveness of nebulized furosemide, further investigation of this potential novel treatment of dyspnea is warranted.

Original languageEnglish (US)
Pages (from-to)424-441
Number of pages18
JournalJournal of Pain and Symptom Management
Volume36
Issue number4
DOIs
StatePublished - Oct 2008
Externally publishedYes

Keywords

  • Furosemide
  • acute disease
  • chronic disease
  • drug administration
  • dyspnea
  • inhalation

ASJC Scopus subject areas

  • Nursing(all)
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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