Near-triploid and near-tetraploid acute lymphoblastic leukemia of childhood

C. H. Pui, A. J. Carroll, D. Head, S. C. Raimondi, J. J. Shuster, W. M. Crist, M. P. Link, M. J. Borowitz, F. G. Behm, V. J. Land, M. B. Nash, D. J. Pullen, A. T. Look

Research output: Contribution to journalArticle

Abstract

Cytogenetic and DNA flow cytometric analyses of leukemic cells from 1,971 children with newly diagnosed acute lymphoblastic leukemia (ALL) identified stem lines with modal chromosome numbers greater than 65 in 26 patients (1.3%). Near-triploidy (66 to 73 chromosomes) was found in six cases and near-tetraploidy (82 to 94 chromosomes) in 20. A striking morphologic finding was the presence of clumped chromatin with grooved nuclei or Rieder cell formation in 20 cases. Other than a sligh excess of the pre-B immunophenotype, the near-triploid cases did not appear to differ substantially from the general ALL population in clinical features. In contrast, near-tetraploid cases were more often associated with a T-cell immunophenotype (47% v 14%, P < .001) and L2 morphology (30% v 22%, P < .01), and were older at diagnosis (median age, 8.6 v 4.8 years, P = .01) than cases with other ploidies. Moreover, an unusually high proportion of near-tetraploid cases tested (6 of 15) expressed one or more of the myeloid-associated antigens CD13, CD15, and CD33. Despite the use of contemporary intensive chemotherapy and short follow-up for most patients, 6 of the 20 near-tetraploid cases have relapsed or died. This study suggests that the near-tetraploide subtype differs from other cases of hyperdiploid > 50 ALL, which have been associated with a favorable prognosis.

Original languageEnglish (US)
Pages (from-to)590-596
Number of pages7
JournalBlood
Volume76
Issue number3
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Pui, C. H., Carroll, A. J., Head, D., Raimondi, S. C., Shuster, J. J., Crist, W. M., Link, M. P., Borowitz, M. J., Behm, F. G., Land, V. J., Nash, M. B., Pullen, D. J., & Look, A. T. (1990). Near-triploid and near-tetraploid acute lymphoblastic leukemia of childhood. Blood, 76(3), 590-596. https://doi.org/10.1182/blood.v76.3.590.bloodjournal763590