Near-IR optical properties of canine prostate tissue using oblique-incidence reflectometry

Shahab Chitchian, Nathaniel M. Fried

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Optical imaging systems utilizing near-infrared light sources such as optical coherence tomography (OCT) have recently been used for imaging the prostate gland. However, the optimal wavelength for deep imaging of the prostate has yet to be determined. The objective of this study is to determine the optimal near-infrared wavelength for OCT imaging of the prostate using a system that has the potential to be used in an in vivo model. An obliqueincidence single point measurement technique using a normal-detector scanning system was implemented to determine the absorption (μa) and reduced scattering coefficients (μ's) of fresh canine prostate tissue, ex vivo, from the diffuse reflectance profile of near-IR light as a function of source-detector distance. The effective attenuation coefficient (μeff) and optical penetration depth (OPD) were then calculated for near-IR wavelengths of 1064, 1307, and 1555 nm. A total of ten canine samples were used for this study. At wavelengths of 1064, 1307, and 1555 nm, the mean absorption coefficients measured 0.08 ± 0.03, 0.12 ± 0.04, and 0.23 ± 0.09 cm-1, respectively. The mean reduced scattering coefficients measured 16.60 ± 0.95, 14.30 ± 1.14, and 10.98 ± 2.35 cm-1. The effective attenuation coefficients were calculated to be 2.00, 2.28, and 2.78 cm-1, yielding OPD's of 0.5, 0.44, and 0.36 cm at 1064, 1307, and 1555 nm. OCT imaging studies of the prostate may benefit from replacement of commonly used 1310 nm broadband light sources with 1064 nm sources.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7548
DOIs
StatePublished - 2010
EventPhotonic Therapeutics and Diagnostics VI - San Francisco, CA, United States
Duration: Jan 23 2010Jan 25 2010

Other

OtherPhotonic Therapeutics and Diagnostics VI
CountryUnited States
CitySan Francisco, CA
Period1/23/101/25/10

Keywords

  • diffuse reflectance spectroscopy
  • OCT
  • optical coherence tomography
  • optical properties
  • prostate

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Chitchian, S., & Fried, N. M. (2010). Near-IR optical properties of canine prostate tissue using oblique-incidence reflectometry. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7548). [75480Z] https://doi.org/10.1117/12.839598