NDRG2: A novel Alzheimer's disease associated protein

Cathy Mitchelmore, Stine Büchmann-Møller, Lene Rask, Mark J. West, Juan C. Troncoso, Niels A. Jensen

Research output: Contribution to journalArticlepeer-review

Abstract

Our understanding of the genes involved in Alzheimer's disease (AD) is incomplete. Using subtractive cloning technology, we discovered that the α/β-hydrolase fold protein gene NDRG2 (NDRG family member 2) is upregulated at both the RNA and protein levels in AD brains. Expression of NDRG2 in affected brains was revealed in (1) cortical pyramidal neurons, (2) senile plaques and (3) cellular processes of dystrophic neurons. Overexpression of two splice variants encoding a long and short NDRG2 isoform in hippocampal pyramidal neurons of transgenic mice resulted in localization of both isoforms to dendritic processes. Taken together, our findings suggest that NDRG2 upregulation is associated with disease pathogenesis in the human brain and provide new insight into the molecular changes that occur in AD.

Original languageEnglish (US)
Pages (from-to)48-58
Number of pages11
JournalNeurobiology of Disease
Volume16
Issue number1
DOIs
StatePublished - Jun 2004

Keywords

  • Alzheimer's disease
  • CA1
  • Dystrophic neurons
  • Hippocampus
  • NDRG
  • Neuronal degeneration
  • Pyramidal neurons
  • Senile plaques
  • Transgenic mice
  • α/β-Hydrolase

ASJC Scopus subject areas

  • Neurology

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