NCCN Task Force report: Adjuvant therapy for breast cancer

Robert W. Carlson, Elizabeth Brown, Harold J. Burstein, William J. Gradishar, Clifford A. Hudis, Charles Loprinzi, Eleftherios Paul Mamounas, Edith A. Perez, Kathleen Pritchard, Peter Ravdin, Abram Recht, George Somlo, Richard L. Theriault, Eric P. Winer, Antonio C Wolff

Research output: Contribution to journalArticle

Abstract

The National Comprehensive Cancer Network (NCCN) first published the NCCN Breast Cancer Treatment Guidelines in 1996. The Guidelines address the treatment of all stages of breast cancer across the spectrum of patient care and have been updated yearly. Adjuvant therapy for breast cancer has undergone an especially rapid evolution over the past few years. Therefore, the NCCN Breast Cancer Guidelines Panel was supplemented by additional experts to form the Adjuvant Therapy Task Force to provide a forum for an extended discussion and expanded input to the adjuvant therapy recommendations for the Breast Cancer Treatment Guidelines. Issues discussed included methods of risk-stratification for recurrence; how biologic markers such as HER2 status, quantitative estrogen receptor, or genetic markers can be incorporated as prognostic or predictive factors; and how age, menopausal status, and estrogen receptor levels impact benefits from chemotherapy and endocrine therapy. Additionally, the task force discussed the strategies for use of aromatase inhibitors in postmenopausal women and the potential incorporation of trastuzumab into adjuvant therapy of women with HER2/neu positive breast cancer. This supplement summarizes the background data and ensuing discussion from the Adjvuant Task Force meeting.

Original languageEnglish (US)
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume4
Issue numberSUPPL. 1
StatePublished - Mar 2006
Externally publishedYes

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Keywords

  • Adjuvant therapy
  • Aromatase inhibitors
  • Breast cancer
  • ER+
  • Estrogen receptors
  • Gene expression profiling
  • HER2
  • Hormone therapy
  • NCCN Clinical Practice Guidelines in Oncology
  • Prognostic factors
  • Risk of recurrence
  • Taxanes

ASJC Scopus subject areas

  • Oncology

Cite this

Carlson, R. W., Brown, E., Burstein, H. J., Gradishar, W. J., Hudis, C. A., Loprinzi, C., Mamounas, E. P., Perez, E. A., Pritchard, K., Ravdin, P., Recht, A., Somlo, G., Theriault, R. L., Winer, E. P., & Wolff, A. C. (2006). NCCN Task Force report: Adjuvant therapy for breast cancer. JNCCN Journal of the National Comprehensive Cancer Network, 4(SUPPL. 1).