Abstract
Voltage-gated sodium channels (NaVs) underlie the initiation of action potentials in various excitable cell types and are regulated by channel-interacting proteins, including the cellular calcium sensor calmodulin and fibroblast growth factor homologous factors. Both of these are known to bind the NaV cytosolic C-terminal domain and modulate the channel's electrophysiology, but it was unknown whether they had any allosteric interactions with each other. A recent rigorous study provides insights into the molecular interactions of these ion channels and their partners that crucially take the cellular landscape into consideration.
Original language | English (US) |
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Article number | 100832 |
Journal | Journal of Biological Chemistry |
Volume | 296 |
DOIs | |
State | Published - Jan 1 2021 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology