Navigating signaling networks: chemotaxis in Dictyostelium discoideum

Jonathan Franca-Koh, Yoichiro Kamimura, Peter Devreotes

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations


Studies of chemotaxis in the social amoeba Dictyostelium discoideum have revealed numerous conserved signaling networks that are activated by chemoattractants. In the presence of a uniformly distributed stimulus, these pathways are transiently activated, but in a gradient they are activated persistently and can be localized to either the front or the back of the cell. Recent studies have begun to elucidate how chemoattractant signaling regulates the three main components of chemotaxis: directional sensing, pseudopod extension, and polarization.

Original languageEnglish (US)
Pages (from-to)333-338
Number of pages6
JournalCurrent Opinion in Genetics and Development
Issue number4
StatePublished - Aug 2006

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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