Navigating signaling networks: chemotaxis in Dictyostelium discoideum

Jonathan Franca-Koh; Yoichiro Kamimura; Peter Devreotes

doi:10.1016/j.gde.2006.06.001

Navigating signaling networks: chemotaxis in Dictyostelium discoideum

Jonathan Franca-Koh, Yoichiro Kamimura, Peter Devreotes

School of Medicine

Research output: Contribution to journal › Review article

Abstract

Studies of chemotaxis in the social amoeba Dictyostelium discoideum have revealed numerous conserved signaling networks that are activated by chemoattractants. In the presence of a uniformly distributed stimulus, these pathways are transiently activated, but in a gradient they are activated persistently and can be localized to either the front or the back of the cell. Recent studies have begun to elucidate how chemoattractant signaling regulates the three main components of chemotaxis: directional sensing, pseudopod extension, and polarization.

Original language	English (US)
Pages (from-to)	333-338
Number of pages	6
Journal	Current Opinion in Genetics and Development
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/j.gde.2006.06.001
State	Published - Aug 1 2006

ASJC Scopus subject areas

Genetics
Developmental Biology

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Franca-Koh, J., Kamimura, Y., & Devreotes, P. (2006). Navigating signaling networks: chemotaxis in Dictyostelium discoideum. Current Opinion in Genetics and Development, 16(4), 333-338. https://doi.org/10.1016/j.gde.2006.06.001

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