TY - JOUR
T1 - Navigating signaling networks
T2 - chemotaxis in Dictyostelium discoideum
AU - Franca-Koh, Jonathan
AU - Kamimura, Yoichiro
AU - Devreotes, Peter
N1 - Funding Information:
The authors wish to acknowledge members of the Devreotes lab, in particular Stacy Willard and Miho Iijima, for helpful comments and are grateful to Linfeng Chen for allowing the inclusion of data from her manuscript in preparation. Owing to space restrictions, many excellent papers could not be cited and the authors apologize to any colleagues whose work was not mentioned. The PND lab is supported by National Institutes of Health grants GM28007 and GM34933.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/8
Y1 - 2006/8
N2 - Studies of chemotaxis in the social amoeba Dictyostelium discoideum have revealed numerous conserved signaling networks that are activated by chemoattractants. In the presence of a uniformly distributed stimulus, these pathways are transiently activated, but in a gradient they are activated persistently and can be localized to either the front or the back of the cell. Recent studies have begun to elucidate how chemoattractant signaling regulates the three main components of chemotaxis: directional sensing, pseudopod extension, and polarization.
AB - Studies of chemotaxis in the social amoeba Dictyostelium discoideum have revealed numerous conserved signaling networks that are activated by chemoattractants. In the presence of a uniformly distributed stimulus, these pathways are transiently activated, but in a gradient they are activated persistently and can be localized to either the front or the back of the cell. Recent studies have begun to elucidate how chemoattractant signaling regulates the three main components of chemotaxis: directional sensing, pseudopod extension, and polarization.
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U2 - 10.1016/j.gde.2006.06.001
DO - 10.1016/j.gde.2006.06.001
M3 - Review article
C2 - 16782326
AN - SCOPUS:33745632621
VL - 16
SP - 333
EP - 338
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
SN - 0959-437X
IS - 4
ER -