Naturally occurring systemic immune responses to HPV antigens do not predict regression of CIN2/3

Cornelia L. Trimble, Shiwen Peng, Christopher Thoburn, Ferdynand Kos, T. C. Wu

Research output: Contribution to journalArticle

Abstract

Essentially all squamous cervical cancers and their precursor lesions, high grade cervical intraepithelial neoplasia (CIN2/3), are caused by persistent human papillomavirus (HPV) infection. However, not all CIN2/3 lesions progress to cancer. In a brief, observational study window monitoring subjects with CIN2/3 from protocol entry (biopsy diagnosis) to definitive therapy (cervical conization) at week 15, in a cohort of 50 subjects, we found that 26% of CIN2/3 lesions associated with HPV16, the genotype most commonly associated with disease, underwent complete histologic regression. Nonetheless, HPV 16specific T cell responses measured in peripheral blood obtained at the time of study entry and at the time of conization were marginally detectable directly ex vivo, and did not correlate with lesion regression. This finding suggests that, in the setting of natural infection, immune responses which are involved in elimination of cervical dysplastic epithelium, are not represented to any great extent in the systemic circulation.

Original languageEnglish (US)
Pages (from-to)799-803
Number of pages5
JournalCancer Immunology, Immunotherapy
Volume59
Issue number5
DOIs
StatePublished - May 1 2010

Keywords

  • Cervical dysplasia
  • Human papillomavirus (hpv)
  • Regression
  • Systemic immune response

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Cancer Research

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