Abstract
Skeletal muscle tissue has an inherent capacity for regeneration following injury. However, severe trauma, such as volumetric muscle loss, overwhelms these natural muscle repair mechanisms prompting the search for a tissue engineering/regenerative medicine approach to promote functional skeletal muscle restoration. A desirable approach involves a bioscaffold that simultaneously acts as an inductive microenvironment and as a cell/drug delivery vehicle to encourage muscle ingrowth. Both biologically active, naturally derived materials (such as extracellular matrix) and carefully engineered synthetic polymers have been developed to provide such a muscle regenerative environment. Next generation naturally derived/synthetic "hybrid materials" would combine the advantageous properties of these materials to create an optimal platform for cell/drug delivery and possess inherent bioactive properties. Advances in scaffolds using muscle tissue engineering are reviewed herein.
Original language | English (US) |
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Pages (from-to) | 208-221 |
Number of pages | 14 |
Journal | Advanced Drug Delivery Reviews |
Volume | 84 |
DOIs | |
State | Published - Apr 1 2015 |
Externally published | Yes |
Keywords
- Electrospinning
- Extracellular matrix (ECM)
- Hybrid materials
- Hydrogel
- Mesh
- Volumetric muscle loss (VML)
ASJC Scopus subject areas
- Pharmaceutical Science