Naturally derived and synthetic scaffolds for skeletal muscle reconstruction

Matthew T. Wolf, Christopher L. Dearth, Sonya B. Sonnenberg, Elizabeth G. Loboa, Stephen F. Badylak

Research output: Contribution to journalReview articlepeer-review


Skeletal muscle tissue has an inherent capacity for regeneration following injury. However, severe trauma, such as volumetric muscle loss, overwhelms these natural muscle repair mechanisms prompting the search for a tissue engineering/regenerative medicine approach to promote functional skeletal muscle restoration. A desirable approach involves a bioscaffold that simultaneously acts as an inductive microenvironment and as a cell/drug delivery vehicle to encourage muscle ingrowth. Both biologically active, naturally derived materials (such as extracellular matrix) and carefully engineered synthetic polymers have been developed to provide such a muscle regenerative environment. Next generation naturally derived/synthetic "hybrid materials" would combine the advantageous properties of these materials to create an optimal platform for cell/drug delivery and possess inherent bioactive properties. Advances in scaffolds using muscle tissue engineering are reviewed herein.

Original languageEnglish (US)
Pages (from-to)208-221
Number of pages14
JournalAdvanced Drug Delivery Reviews
StatePublished - Apr 1 2015
Externally publishedYes


  • Electrospinning
  • Extracellular matrix (ECM)
  • Hybrid materials
  • Hydrogel
  • Mesh
  • Volumetric muscle loss (VML)

ASJC Scopus subject areas

  • Pharmaceutical Science


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