Natural product leads for drug discovery: Isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents

Songpo Guo, Suresh K. Tipparaju, Scott D. Pegan, Baojie Wan, Shunyan Mo, Jimmy Orjala, Andrew D. Mesecar, Scott G. Franzblau, Alan P. Kozikowski

Research output: Contribution to journalArticlepeer-review

Abstract

Indolo[2,3-a]carbazole based inhibitors were synthesized from readily available indigo via a seven-step linear synthetic sequence with a moderate overall yield. The inhibitors were selectively and readily functionalized at the nitrogen on the indole portion of the carbazole unit. The synthesized analogs displayed moderate inhibitory activities toward Bacillus anthracis and Mycobacterium tuberculosis, indicating that indolo[2,3-a]carbazoles could serve as promising leads in the development of new drugs to combat anthrax and tuberculosis infections.

Original languageEnglish (US)
Pages (from-to)7126-7130
Number of pages5
JournalBioorganic and Medicinal Chemistry
Volume17
Issue number20
DOIs
StatePublished - Oct 15 2009

Keywords

  • Anthrax
  • Carbazole
  • Tuberculosis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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