TY - JOUR
T1 - Natural ligand of mouse CD1d1
T2 - Cellular glycosylphosphatidylinositol
AU - Joyce, Sebastian
AU - Woods, Amina S.
AU - Yewdell, Jonathan W.
AU - Bennink, Jack R.
AU - De Silva, A. Dharshan
AU - Boesteanu, Alina
AU - Balk, Steven P.
AU - Cotter, Robert J.
AU - Brutkiewicz, Randy R.
PY - 1998/3/6
Y1 - 1998/3/6
N2 - Mouse CD1d1, a member of the CD1 family of evolutionarily conserved major histocompatibility antigen-like molecules, controls the differentiation and function of a T lymphocyte subset, NK+ natural T cells, proposed to regulate immune responses. The CD1d1 crystal structure revealed a large hydrophobic binding site occupied by a ligand of unknown chemical nature. Mass spectrometry and metabolic radiolabeling were used to identify cellular glycosylphosphatidylinositol as major natural ligand of CD1d1. CD1d1 bound glycosylphosphatidylinositol through its phosphatidylinositol aspect with high affinity. Glycosylphosphatidylinositol or another glycolipid could be a candidate natural ligand for CD1d1-restricted T cells.
AB - Mouse CD1d1, a member of the CD1 family of evolutionarily conserved major histocompatibility antigen-like molecules, controls the differentiation and function of a T lymphocyte subset, NK+ natural T cells, proposed to regulate immune responses. The CD1d1 crystal structure revealed a large hydrophobic binding site occupied by a ligand of unknown chemical nature. Mass spectrometry and metabolic radiolabeling were used to identify cellular glycosylphosphatidylinositol as major natural ligand of CD1d1. CD1d1 bound glycosylphosphatidylinositol through its phosphatidylinositol aspect with high affinity. Glycosylphosphatidylinositol or another glycolipid could be a candidate natural ligand for CD1d1-restricted T cells.
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U2 - 10.1126/science.279.5356.1541
DO - 10.1126/science.279.5356.1541
M3 - Article
C2 - 9488653
AN - SCOPUS:0032489652
SN - 0036-8075
VL - 279
SP - 1541
EP - 1544
JO - Science
JF - Science
IS - 5356
ER -