Natural killer T (NKT) cells in mice and men

Nicola Mary Heller, Rosa Berga-Bolanos, Lynette Naler, Jyoti Misra Sen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Natural killer T (NKT) cells are innate natural killer (NK)-like cells that express a limited repertoire of T cell receptors (TCRs). Akin to other innate cells, NKT cells acquire functional characteristics during development in the thymus. Similar to mature effector T cells, murine NKT cells have been subdivided into effector subsets based on expression of transcription factors Gata3, ROR?t, or Tbet, and by the cytokine expression. In this chapter we have attempted to place the available research on human and murine NKT cells side by side even though making direct connections remains challenging, as research in the two species has progressed independently.

Original languageEnglish (US)
Title of host publicationSignaling Mechanisms Regulating T Cell Diversity and Function
PublisherCRC Press
Pages119-146
Number of pages28
ISBN (Electronic)9781498705097
ISBN (Print)9781498705080
DOIs
StatePublished - Jan 1 2017

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Heller, N. M., Berga-Bolanos, R., Naler, L., & Sen, J. M. (2017). Natural killer T (NKT) cells in mice and men. In Signaling Mechanisms Regulating T Cell Diversity and Function (pp. 119-146). CRC Press. https://doi.org/10.1201/9781315371689