Natural killer cells in inflammatory heart disease

Su Fey Ong, Noel R. Rose, Daniela Čiháková

Research output: Research - peer-reviewReview article

Abstract

Despite of a multitude of excellent studies, the regulatory role of natural killer (NK) cells in the pathogenesis of inflammatory cardiac disease is greatly underappreciated. Clinical abnormalities in the numbers and functions of NK cells are observed in myocarditis and inflammatory dilated cardiomyopathy (DCMi) as well as in cardiac transplant rejection [1–6]. Because treatment of these disorders remains largely symptomatic in nature, patients have little options for targeted therapies [7,8]. However, blockade of NK cells and their receptors can protect against inflammation and damage in animal models of cardiac injury and inflammation. In these models, NK cells suppress the maturation and trafficking of inflammatory cells, alter the local cytokine and chemokine environments, and induce apoptosis in nearby resident and hematopoietic cells [1,9,10]. This review will dissect each protective mechanism employed by NK cells and explore how their properties might be exploited for their therapeutic potential.

LanguageEnglish (US)
Pages26-33
Number of pages8
JournalClinical Immunology
Volume175
DOIs
StatePublished - Feb 1 2017

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Natural Killer Cells
Heart Diseases
Therapeutics
Inflammation
Natural Killer Cell Receptors
Myocarditis
Graft Rejection
Dilated Cardiomyopathy
Chemokines
Animal Models
Apoptosis
Cytokines
Wounds and Injuries

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Natural killer cells in inflammatory heart disease. / Ong, Su Fey; Rose, Noel R.; Čiháková, Daniela.

In: Clinical Immunology, Vol. 175, 01.02.2017, p. 26-33.

Research output: Research - peer-reviewReview article

Ong, Su Fey ; Rose, Noel R. ; Čiháková, Daniela. / Natural killer cells in inflammatory heart disease. In: Clinical Immunology. 2017 ; Vol. 175. pp. 26-33
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