TY - JOUR
T1 - Natural killer cells, glutathione, cytokines, and innate immunity against Mycobacterium tuberculosis
AU - Millman, Ariel C.
AU - Salman, Marwa
AU - Dayaram, Yaswant K.
AU - Connell, Nancy D.
AU - Venketaraman, Vishwanath
PY - 2008/3/1
Y1 - 2008/3/1
N2 - It is becoming increasingly apparent that natural killer (NK) cells play a crucial role in innate defense mechanisms against Mycobacterium tuberculosis infection. Furthermore, NK cell functions are dependent on adequate levels of glutathione. In this study, we examined whether the NK cell-mediated growth control of intracellular M. tuberculosis is dependent on adequate levels of glutathione. We investigated the effects of glutathione both alone and in combination with interleukin-2 (IL-2) or IL-12 or both in modulating NK cell functions, such as cytolytic activity, activating receptor expression, induction of apoptosis, and cytokine synthesis. Our results strongly indicate that glutathione in combination with IL-2+IL-12 augments NK cell functions, leading to control M. tuberculosis infection.
AB - It is becoming increasingly apparent that natural killer (NK) cells play a crucial role in innate defense mechanisms against Mycobacterium tuberculosis infection. Furthermore, NK cell functions are dependent on adequate levels of glutathione. In this study, we examined whether the NK cell-mediated growth control of intracellular M. tuberculosis is dependent on adequate levels of glutathione. We investigated the effects of glutathione both alone and in combination with interleukin-2 (IL-2) or IL-12 or both in modulating NK cell functions, such as cytolytic activity, activating receptor expression, induction of apoptosis, and cytokine synthesis. Our results strongly indicate that glutathione in combination with IL-2+IL-12 augments NK cell functions, leading to control M. tuberculosis infection.
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U2 - 10.1089/jir.2007.0095
DO - 10.1089/jir.2007.0095
M3 - Article
C2 - 18338948
AN - SCOPUS:40749105711
SN - 1079-9907
VL - 28
SP - 153
EP - 165
JO - Journal of Interferon and Cytokine Research
JF - Journal of Interferon and Cytokine Research
IS - 3
ER -