Natural killer cell activity of prostatic cancer patients

B. K. Choe; P. Frost; M. K. Morrison; N. R. Rose

doi:10.1080/07357908709170101

Natural killer cell activity of prostatic cancer patients

B. K. Choe, P. Frost, M. K. Morrison, N. R. Rose

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Natural killer (NK) cell activity of prostatic cancer patients was compared with that of control groups by the radioactive indium (^IIIIn) release assay using the K562 and H494 cells as targets. Patients suffering from advanced prostatic cancer (clinical stages C and D) exhibited significantly lower NK activity against K562 cells (28 ± 18% than did the normal group (41 ± 19% The lower NK activity of these patients is not related to their age, since patients in the same age range with localized cancer (stage B) or benign prostatic hyperplasia did not show low NK activity (37% ± 19% This lower NK activity is not due to a depletion of the NK cell precursor population, since the NK activity of advanced cancer patients improves significantly after in vitro incubation with interferon. The NK activity of normal subjects or patient groups showed wide fluctuations during the 18-month observation period. Because of these interassay variations, it is necessary to use standard control subjects during long-term monitoring of the NK activity of the patients.

Original language	English (US)
Pages (from-to)	285-291
Number of pages	7
Journal	Cancer Investigation
Volume	5
Issue number	4
DOIs	https://doi.org/10.1080/07357908709170101
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Natural killer cell activity of prostatic cancer patients",

abstract = "Natural killer (NK) cell activity of prostatic cancer patients was compared with that of control groups by the radioactive indium (IIIIn) release assay using the K562 and H494 cells as targets. Patients suffering from advanced prostatic cancer (clinical stages C and D) exhibited significantly lower NK activity against K562 cells (28 ± 18% than did the normal group (41 ± 19% The lower NK activity of these patients is not related to their age, since patients in the same age range with localized cancer (stage B) or benign prostatic hyperplasia did not show low NK activity (37% ± 19% This lower NK activity is not due to a depletion of the NK cell precursor population, since the NK activity of advanced cancer patients improves significantly after in vitro incubation with interferon. The NK activity of normal subjects or patient groups showed wide fluctuations during the 18-month observation period. Because of these interassay variations, it is necessary to use standard control subjects during long-term monitoring of the NK activity of the patients.",

author = "Choe, {B. K.} and P. Frost and Morrison, {M. K.} and Rose, {N. R.}",

note = "Funding Information: Supported by U.S. Public Health Servim Grant #CAI6426 from the National Institutes of Health.",

year = "1987",

doi = "10.1080/07357908709170101",

language = "English (US)",

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journal = "Cancer Investigation",

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TY - JOUR

T1 - Natural killer cell activity of prostatic cancer patients

AU - Choe, B. K.

AU - Frost, P.

AU - Morrison, M. K.

AU - Rose, N. R.

N1 - Funding Information: Supported by U.S. Public Health Servim Grant #CAI6426 from the National Institutes of Health.

PY - 1987

Y1 - 1987

N2 - Natural killer (NK) cell activity of prostatic cancer patients was compared with that of control groups by the radioactive indium (IIIIn) release assay using the K562 and H494 cells as targets. Patients suffering from advanced prostatic cancer (clinical stages C and D) exhibited significantly lower NK activity against K562 cells (28 ± 18% than did the normal group (41 ± 19% The lower NK activity of these patients is not related to their age, since patients in the same age range with localized cancer (stage B) or benign prostatic hyperplasia did not show low NK activity (37% ± 19% This lower NK activity is not due to a depletion of the NK cell precursor population, since the NK activity of advanced cancer patients improves significantly after in vitro incubation with interferon. The NK activity of normal subjects or patient groups showed wide fluctuations during the 18-month observation period. Because of these interassay variations, it is necessary to use standard control subjects during long-term monitoring of the NK activity of the patients.

AB - Natural killer (NK) cell activity of prostatic cancer patients was compared with that of control groups by the radioactive indium (IIIIn) release assay using the K562 and H494 cells as targets. Patients suffering from advanced prostatic cancer (clinical stages C and D) exhibited significantly lower NK activity against K562 cells (28 ± 18% than did the normal group (41 ± 19% The lower NK activity of these patients is not related to their age, since patients in the same age range with localized cancer (stage B) or benign prostatic hyperplasia did not show low NK activity (37% ± 19% This lower NK activity is not due to a depletion of the NK cell precursor population, since the NK activity of advanced cancer patients improves significantly after in vitro incubation with interferon. The NK activity of normal subjects or patient groups showed wide fluctuations during the 18-month observation period. Because of these interassay variations, it is necessary to use standard control subjects during long-term monitoring of the NK activity of the patients.

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JO - Cancer Investigation

JF - Cancer Investigation

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ER -

Natural killer cell activity of prostatic cancer patients

Abstract

ASJC Scopus subject areas

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