Natural killer cell activity during measles

Diane Griffin, B. J. Ward, E. Jauregui, Richard Johnson, A. Vaisberg

Research output: Contribution to journalArticle

Abstract

Natural killer cells are postulated to play an important role in host anti-viral defences. We measured natural killer cell activity in 30 individuals with acute measles (73 ± 21 lytic units (LU)/107 cells) and 16 individuals with other infectious diseases (149 ± 95 LU) and found it reduced compared with values for adults (375 ± 70 LU; P <0.001) or children (300 ± 73 LU, P <0.01) without infection. Reduced natural killer cell activity was found in measles patients with (84 ± 30 LU) and without (55 ± 18 LU) complications and was present for at least 3 weeks after the onset of the rash. Activity was increased by in vitro exposure of cells to interleukin-2. Depressed natural killer cell activity parallels in time the suppression of other parameters of cell-mediated immunity that occurs during measles.

Original languageEnglish (US)
Pages (from-to)218-224
Number of pages7
JournalClinical and Experimental Immunology
Volume81
Issue number2
StatePublished - 1990

Fingerprint

Measles
Natural Killer Cells
Exanthema
Cellular Immunity
Interleukin-2
Communicable Diseases
Infection

Keywords

  • interferon
  • interleukin-2
  • measles
  • natural killer cells

ASJC Scopus subject areas

  • Immunology

Cite this

Griffin, D., Ward, B. J., Jauregui, E., Johnson, R., & Vaisberg, A. (1990). Natural killer cell activity during measles. Clinical and Experimental Immunology, 81(2), 218-224.

Natural killer cell activity during measles. / Griffin, Diane; Ward, B. J.; Jauregui, E.; Johnson, Richard; Vaisberg, A.

In: Clinical and Experimental Immunology, Vol. 81, No. 2, 1990, p. 218-224.

Research output: Contribution to journalArticle

Griffin, D, Ward, BJ, Jauregui, E, Johnson, R & Vaisberg, A 1990, 'Natural killer cell activity during measles', Clinical and Experimental Immunology, vol. 81, no. 2, pp. 218-224.
Griffin, Diane ; Ward, B. J. ; Jauregui, E. ; Johnson, Richard ; Vaisberg, A. / Natural killer cell activity during measles. In: Clinical and Experimental Immunology. 1990 ; Vol. 81, No. 2. pp. 218-224.
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