Natural killer cell activity during measles

D. E. Griffin; B. J. Ward; E. Jauregui; R. T. Johnson; A. Vaisberg

doi:10.1111/j.1365-2249.1990.tb03321.x

Natural killer cell activity during measles

D. E. Griffin, B. J. Ward, E. Jauregui, R. T. Johnson, A. Vaisberg

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Natural killer cells are postulated to play an important role in host anti-viral defences. We measured natural killer cell activity in 30 individuals with acute measles (73 ± 21 lytic units (LU)/10⁷ cells) and 16 individuals with other infectious diseases (149 ± 95 LU) and found it reduced compared with values for adults (375 ± 70 LU; P < 0.001) or children (300 ± 73 LU, P < 0.01) without infection. Reduced natural killer cell activity was found in measles patients with (84 ± 30 LU) and without (55 ± 18 LU) complications and was present for at least 3 weeks after the onset of the rash. Activity was increased by in vitro exposure of cells to interleukin-2. Depressed natural killer cell activity parallels in time the suppression of other parameters of cell-mediated immunity that occurs during measles.

Original language	English (US)
Pages (from-to)	218-224
Number of pages	7
Journal	Clinical and Experimental Immunology
Volume	81
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2249.1990.tb03321.x
State	Published - 1990

Keywords

interferon
interleukin-2
measles
natural killer cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1111/j.1365-2249.1990.tb03321.x

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title = "Natural killer cell activity during measles",

abstract = "Natural killer cells are postulated to play an important role in host anti-viral defences. We measured natural killer cell activity in 30 individuals with acute measles (73 ± 21 lytic units (LU)/107 cells) and 16 individuals with other infectious diseases (149 ± 95 LU) and found it reduced compared with values for adults (375 ± 70 LU; P < 0.001) or children (300 ± 73 LU, P < 0.01) without infection. Reduced natural killer cell activity was found in measles patients with (84 ± 30 LU) and without (55 ± 18 LU) complications and was present for at least 3 weeks after the onset of the rash. Activity was increased by in vitro exposure of cells to interleukin-2. Depressed natural killer cell activity parallels in time the suppression of other parameters of cell-mediated immunity that occurs during measles.",

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AU - Griffin, D. E.

AU - Ward, B. J.

AU - Jauregui, E.

AU - Johnson, R. T.

AU - Vaisberg, A.

PY - 1990

Y1 - 1990

N2 - Natural killer cells are postulated to play an important role in host anti-viral defences. We measured natural killer cell activity in 30 individuals with acute measles (73 ± 21 lytic units (LU)/107 cells) and 16 individuals with other infectious diseases (149 ± 95 LU) and found it reduced compared with values for adults (375 ± 70 LU; P < 0.001) or children (300 ± 73 LU, P < 0.01) without infection. Reduced natural killer cell activity was found in measles patients with (84 ± 30 LU) and without (55 ± 18 LU) complications and was present for at least 3 weeks after the onset of the rash. Activity was increased by in vitro exposure of cells to interleukin-2. Depressed natural killer cell activity parallels in time the suppression of other parameters of cell-mediated immunity that occurs during measles.

AB - Natural killer cells are postulated to play an important role in host anti-viral defences. We measured natural killer cell activity in 30 individuals with acute measles (73 ± 21 lytic units (LU)/107 cells) and 16 individuals with other infectious diseases (149 ± 95 LU) and found it reduced compared with values for adults (375 ± 70 LU; P < 0.001) or children (300 ± 73 LU, P < 0.01) without infection. Reduced natural killer cell activity was found in measles patients with (84 ± 30 LU) and without (55 ± 18 LU) complications and was present for at least 3 weeks after the onset of the rash. Activity was increased by in vitro exposure of cells to interleukin-2. Depressed natural killer cell activity parallels in time the suppression of other parameters of cell-mediated immunity that occurs during measles.

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KW - measles

KW - natural killer cells

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Natural killer cell activity during measles

Abstract

Keywords

ASJC Scopus subject areas

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