Natural history of venous morphologic changes in dialysis access stenosis

Timmy Lee, Maheshika Somarathna, Arjan Hura, Yang Wang, Begona Campos, Lois J Arend, Rino Munda, Prabir Roy-Chaudhury

Research output: Contribution to journalArticle

Abstract

Purpose: Venous stenosis secondary to neointimal hyperplasia is a major etiology of early arteriovenous fistula (AVF) failure. The natural history of AVF failure is likely influenced by progressive vascular insults to the vein prior to and after AVF creation. The main objectives of this study were to (1) provide a histologic and morphometric description of non-chronic kidney disease (CKD), upper extremity vein specimens and (2) perform a morphometric analysis to study venous histology from non-CKD upper extremity veins, veins collected at the time of new vascular access surgery and veins collected from failed stenotic AVFs. Methods: Vein samples from 11 non-CKD deceased donors, 29 subjects receiving new vascular access creation and 20 subjects with stenotic failed AVFs were collected for histologic and morphometric analysis. Results: The mean values of average intima/media thickness ± S.E. from veins collected from non-CKD subjects, subjects receiving new vascular access and subjects with stenotic AVFs were 0.16±0.02, 0.43±0.07 and 3.84±0.55, respectively (p

Original languageEnglish (US)
Pages (from-to)298-305
Number of pages8
JournalJournal of Vascular Access
Volume15
Issue number4
DOIs
StatePublished - 2014

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Natural History
Dialysis
Veins
Pathologic Constriction
Kidney Diseases
Blood Vessels
Arteriovenous Fistula
Upper Extremity
Hyperplasia
Histology

Keywords

  • Arteriovenous access
  • Dialysis vascular access
  • Venous neointimal hyperplasia

ASJC Scopus subject areas

  • Surgery
  • Nephrology

Cite this

Lee, T., Somarathna, M., Hura, A., Wang, Y., Campos, B., Arend, L. J., ... Roy-Chaudhury, P. (2014). Natural history of venous morphologic changes in dialysis access stenosis. Journal of Vascular Access, 15(4), 298-305. https://doi.org/10.5301/jva.5000212

Natural history of venous morphologic changes in dialysis access stenosis. / Lee, Timmy; Somarathna, Maheshika; Hura, Arjan; Wang, Yang; Campos, Begona; Arend, Lois J; Munda, Rino; Roy-Chaudhury, Prabir.

In: Journal of Vascular Access, Vol. 15, No. 4, 2014, p. 298-305.

Research output: Contribution to journalArticle

Lee, T, Somarathna, M, Hura, A, Wang, Y, Campos, B, Arend, LJ, Munda, R & Roy-Chaudhury, P 2014, 'Natural history of venous morphologic changes in dialysis access stenosis', Journal of Vascular Access, vol. 15, no. 4, pp. 298-305. https://doi.org/10.5301/jva.5000212
Lee, Timmy ; Somarathna, Maheshika ; Hura, Arjan ; Wang, Yang ; Campos, Begona ; Arend, Lois J ; Munda, Rino ; Roy-Chaudhury, Prabir. / Natural history of venous morphologic changes in dialysis access stenosis. In: Journal of Vascular Access. 2014 ; Vol. 15, No. 4. pp. 298-305.
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