TY - JOUR
T1 - Natural history of older adults with impaired kidney function
T2 - The InCHIANTI study
AU - Giannelli, Sandra V.
AU - Graf, Christophe E.
AU - Herrmann, François R.
AU - Michel, Jean Pierre
AU - Patel, Kushang V.
AU - Pizzarelli, Francesco
AU - Ferrucci, Luigi
AU - Guralnik, Jack
PY - 2011/10/1
Y1 - 2011/10/1
N2 - The aim of this study was to assess the kidney function of an older community-dwelling population at baseline and appraise its evolution after 3 years of follow-up in terms of chronic kidney disease (CKD) stage progression, magnitude of glomerular filtration rate (GFR) changes, and value of serum creatinine. This was a prospective population-based study of 676 Italian participants, aged 65 years and older. GFR was estimated using the Cockcroft-Gault equation and the Modification of Diet in Renal Disease Study equation. Using the Cockcroft-Gault equation. A total of 33% of participants had criteria of CKD (GFR90mL/min) at baseline worsened to stage 2 and 10% worsened to stage 3. An abnormal high level of serum creatinine at baseline did not help to predict who might worsen at follow-up. Older people with CKD displayed a low progression of renal disease and therefore are at higher risk for co-morbidities related to CKD than for progression to end-stage renal disease.
AB - The aim of this study was to assess the kidney function of an older community-dwelling population at baseline and appraise its evolution after 3 years of follow-up in terms of chronic kidney disease (CKD) stage progression, magnitude of glomerular filtration rate (GFR) changes, and value of serum creatinine. This was a prospective population-based study of 676 Italian participants, aged 65 years and older. GFR was estimated using the Cockcroft-Gault equation and the Modification of Diet in Renal Disease Study equation. Using the Cockcroft-Gault equation. A total of 33% of participants had criteria of CKD (GFR90mL/min) at baseline worsened to stage 2 and 10% worsened to stage 3. An abnormal high level of serum creatinine at baseline did not help to predict who might worsen at follow-up. Older people with CKD displayed a low progression of renal disease and therefore are at higher risk for co-morbidities related to CKD than for progression to end-stage renal disease.
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U2 - 10.1089/rej.2011.1179
DO - 10.1089/rej.2011.1179
M3 - Article
C2 - 21954982
AN - SCOPUS:80054990853
SN - 1549-1684
VL - 14
SP - 513
EP - 523
JO - Rejuvenation Research
JF - Rejuvenation Research
IS - 5
ER -