Natural history of hepatitis C

David L Thomas, Leonard B. Seeff

Research output: Contribution to journalArticle

Abstract

The outcome of hepatitis C is defined by the rate of spontaneous recovery from the acute infection and the impact of persistent viremia in patients who fail to recover. Persistent viremia is associated with necroinflammation of the liver and induces fibrosis progression at a rate that is determined, to some extent, by factors such as excess alcohol intake, advanced age, and immunosuppression. The endpoint of fibrosis progression is cirrhosis, which occurs only in some persons and may clinically manifest as end-stage liver disease or hepatocellular carcinoma. Based on current projections, the incidences of end-stage liver disease and hepatocellular carcinoma are expected to increase in the next decade. Therefore, future HCV natural history research is appropriately focusing on the identification of persons at risk for disease progression and evaluating the impact of treatment on the course of disease.

Original languageEnglish (US)
Pages (from-to)383-398
Number of pages16
JournalClinics in Liver Disease
Volume9
Issue number3
DOIs
StatePublished - Aug 2005

Fingerprint

End Stage Liver Disease
Viremia
Hepatitis C
Hepatocellular Carcinoma
Fibrosis
Natural History
Liver Cirrhosis
Immunosuppression
Disease Progression
Alcohols
Incidence
Infection
Research
Therapeutics

ASJC Scopus subject areas

  • Hepatology

Cite this

Natural history of hepatitis C. / Thomas, David L; Seeff, Leonard B.

In: Clinics in Liver Disease, Vol. 9, No. 3, 08.2005, p. 383-398.

Research output: Contribution to journalArticle

Thomas, David L ; Seeff, Leonard B. / Natural history of hepatitis C. In: Clinics in Liver Disease. 2005 ; Vol. 9, No. 3. pp. 383-398.
@article{b4110788bcf546b4a0243619dab359a6,
title = "Natural history of hepatitis C",
abstract = "The outcome of hepatitis C is defined by the rate of spontaneous recovery from the acute infection and the impact of persistent viremia in patients who fail to recover. Persistent viremia is associated with necroinflammation of the liver and induces fibrosis progression at a rate that is determined, to some extent, by factors such as excess alcohol intake, advanced age, and immunosuppression. The endpoint of fibrosis progression is cirrhosis, which occurs only in some persons and may clinically manifest as end-stage liver disease or hepatocellular carcinoma. Based on current projections, the incidences of end-stage liver disease and hepatocellular carcinoma are expected to increase in the next decade. Therefore, future HCV natural history research is appropriately focusing on the identification of persons at risk for disease progression and evaluating the impact of treatment on the course of disease.",
author = "Thomas, {David L} and Seeff, {Leonard B.}",
year = "2005",
month = "8",
doi = "10.1016/j.cld.2005.05.003",
language = "English (US)",
volume = "9",
pages = "383--398",
journal = "Clinics in Liver Disease",
issn = "1089-3261",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Natural history of hepatitis C

AU - Thomas, David L

AU - Seeff, Leonard B.

PY - 2005/8

Y1 - 2005/8

N2 - The outcome of hepatitis C is defined by the rate of spontaneous recovery from the acute infection and the impact of persistent viremia in patients who fail to recover. Persistent viremia is associated with necroinflammation of the liver and induces fibrosis progression at a rate that is determined, to some extent, by factors such as excess alcohol intake, advanced age, and immunosuppression. The endpoint of fibrosis progression is cirrhosis, which occurs only in some persons and may clinically manifest as end-stage liver disease or hepatocellular carcinoma. Based on current projections, the incidences of end-stage liver disease and hepatocellular carcinoma are expected to increase in the next decade. Therefore, future HCV natural history research is appropriately focusing on the identification of persons at risk for disease progression and evaluating the impact of treatment on the course of disease.

AB - The outcome of hepatitis C is defined by the rate of spontaneous recovery from the acute infection and the impact of persistent viremia in patients who fail to recover. Persistent viremia is associated with necroinflammation of the liver and induces fibrosis progression at a rate that is determined, to some extent, by factors such as excess alcohol intake, advanced age, and immunosuppression. The endpoint of fibrosis progression is cirrhosis, which occurs only in some persons and may clinically manifest as end-stage liver disease or hepatocellular carcinoma. Based on current projections, the incidences of end-stage liver disease and hepatocellular carcinoma are expected to increase in the next decade. Therefore, future HCV natural history research is appropriately focusing on the identification of persons at risk for disease progression and evaluating the impact of treatment on the course of disease.

UR - http://www.scopus.com/inward/record.url?scp=22044433989&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22044433989&partnerID=8YFLogxK

U2 - 10.1016/j.cld.2005.05.003

DO - 10.1016/j.cld.2005.05.003

M3 - Article

C2 - 16023972

AN - SCOPUS:22044433989

VL - 9

SP - 383

EP - 398

JO - Clinics in Liver Disease

JF - Clinics in Liver Disease

SN - 1089-3261

IS - 3

ER -