TY - JOUR
T1 - Natural course of choroidal neovascular membranes within the foveal avascular zone in senile macular degeneration
AU - Bressler, Susan B.
AU - Bressler, Neil M.
AU - Fine, Stuart L.
AU - Hillis, Argye
AU - Murphy, Robert P.
AU - Olk, R. Joseph
AU - Patz, Arnall
PY - 1982/2
Y1 - 1982/2
N2 - We divided 96 eyes (93 patients) with senile macular degeneration and choroidal neovascular membranes into two groups-those with juxtafoveal membranes (1 to 250 μ from the center of the foveal avascular zone) and those with subfoveal membranes (0 μ from the center of the zone). After an average follow-up period of 21 months, one of 38 eyes in the juxtafoveal group (3%) had improved two or more lines on the Snellen chart, three eyes (8%) had remained the same, and 34 eyes (89%) had lost two or more lines on the Snellen chart. Although 35 of the 38 eyes (92%) had had initial visual acuities of 6 30 ( 20 100) or better, 27 eyes (71%) had become legally blind. Of the 58 eyes in the subfoveal group, 18 (31%) had remained the same or improved and 40 (69%) had lost two or more lines on the Snellen chart; 41 (70%) had final visual acuities of 6 60 ( 20 200) or worse. Of the 26 eyes in the subfoveal group that had had initial visual acuities of 6 60 ( 20 100) or better (45%), four (15%) had stayed the same and 22 (85%) had lost two or more lines on the Snellen chart. Fourteen of the 26 eyes (54%) had final visual acuities of 6 60 ( 20 200) or worse. Exudative maculopathy developed in the second eye in 13% of patients who initially had unilateral choroidal neovascularization after 12 months, in 22% after 24 months, and in 29% after 36 months, using life table analysis.
AB - We divided 96 eyes (93 patients) with senile macular degeneration and choroidal neovascular membranes into two groups-those with juxtafoveal membranes (1 to 250 μ from the center of the foveal avascular zone) and those with subfoveal membranes (0 μ from the center of the zone). After an average follow-up period of 21 months, one of 38 eyes in the juxtafoveal group (3%) had improved two or more lines on the Snellen chart, three eyes (8%) had remained the same, and 34 eyes (89%) had lost two or more lines on the Snellen chart. Although 35 of the 38 eyes (92%) had had initial visual acuities of 6 30 ( 20 100) or better, 27 eyes (71%) had become legally blind. Of the 58 eyes in the subfoveal group, 18 (31%) had remained the same or improved and 40 (69%) had lost two or more lines on the Snellen chart; 41 (70%) had final visual acuities of 6 60 ( 20 200) or worse. Of the 26 eyes in the subfoveal group that had had initial visual acuities of 6 60 ( 20 100) or better (45%), four (15%) had stayed the same and 22 (85%) had lost two or more lines on the Snellen chart. Fourteen of the 26 eyes (54%) had final visual acuities of 6 60 ( 20 200) or worse. Exudative maculopathy developed in the second eye in 13% of patients who initially had unilateral choroidal neovascularization after 12 months, in 22% after 24 months, and in 29% after 36 months, using life table analysis.
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U2 - 10.1016/0002-9394(82)90410-X
DO - 10.1016/0002-9394(82)90410-X
M3 - Article
C2 - 6175215
AN - SCOPUS:0020037050
SN - 0002-9394
VL - 93
SP - 157
EP - 163
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 2
ER -