Abstract
Natural cell-mediated cytotoxicity was studied in 24 patients with cutaneous T-cell lymphomas and in 18 age- and sex-matched controls studied concomitantly. Percent cytotoxicity was determined by 4-h 51Cr release assay using K562 targets at effector to target ratios of 100:1, 50:1, and 25:1. Mean percent cytotoxicity was significantly lower in patients than in controls at an effector to target cell ratio of 100:1. Likewise, decreased cytotoxicity was found at effector to target ratios of 50:1 and 25:1, although this difference was not significant. When natural killer activity was analyzed separately for males and females, cytotoxicity was lower in both, although the decrease was significant only for male patients. Impairment of natural killer activity did not correlate with blood zinc levels, but appeared to correlate with stage of disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 176-178 |
| Number of pages | 3 |
| Journal | Journal of Investigative Dermatology |
| Volume | 81 |
| Issue number | 2 |
| State | Published - 1983 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Dermatology
Cite this
Natural cell-mediated cytotoxicity in cutaneous T-cell lymphomas. / Neilan, B. A.; Vonderheid, E. C.; O'Neill, K. J.
In: Journal of Investigative Dermatology, Vol. 81, No. 2, 1983, p. 176-178.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Natural cell-mediated cytotoxicity in cutaneous T-cell lymphomas
AU - Neilan, B. A.
AU - Vonderheid, E. C.
AU - O'Neill, K. J.
PY - 1983
Y1 - 1983
N2 - Natural cell-mediated cytotoxicity was studied in 24 patients with cutaneous T-cell lymphomas and in 18 age- and sex-matched controls studied concomitantly. Percent cytotoxicity was determined by 4-h 51Cr release assay using K562 targets at effector to target ratios of 100:1, 50:1, and 25:1. Mean percent cytotoxicity was significantly lower in patients than in controls at an effector to target cell ratio of 100:1. Likewise, decreased cytotoxicity was found at effector to target ratios of 50:1 and 25:1, although this difference was not significant. When natural killer activity was analyzed separately for males and females, cytotoxicity was lower in both, although the decrease was significant only for male patients. Impairment of natural killer activity did not correlate with blood zinc levels, but appeared to correlate with stage of disease.
AB - Natural cell-mediated cytotoxicity was studied in 24 patients with cutaneous T-cell lymphomas and in 18 age- and sex-matched controls studied concomitantly. Percent cytotoxicity was determined by 4-h 51Cr release assay using K562 targets at effector to target ratios of 100:1, 50:1, and 25:1. Mean percent cytotoxicity was significantly lower in patients than in controls at an effector to target cell ratio of 100:1. Likewise, decreased cytotoxicity was found at effector to target ratios of 50:1 and 25:1, although this difference was not significant. When natural killer activity was analyzed separately for males and females, cytotoxicity was lower in both, although the decrease was significant only for male patients. Impairment of natural killer activity did not correlate with blood zinc levels, but appeared to correlate with stage of disease.
UR - http://www.scopus.com/inward/record.url?scp=0020957453&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020957453&partnerID=8YFLogxK
M3 - Article
C2 - 6603488
AN - SCOPUS:0020957453
VL - 81
SP - 176
EP - 178
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 2
ER -