Natural and Synthetic Huperzine A: Effect on Cholinergic Function in Vitro and in Vivo

ISRAEL HANIN; XI‐CAN ‐C TANG; GISELA L. KINDEL; ALAN P. KOZIKOWSKI

doi:10.1111/j.1749-6632.1993.tb23071.x

Natural and Synthetic Huperzine A: Effect on Cholinergic Function in Vitro and in Vivo

ISRAEL HANIN, XI‐CAN ‐C TANG, GISELA L. KINDEL, ALAN P. KOZIKOWSKI

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6 Scopus citations

Abstract

Huperzine A has been shown to be useful in the treatment of symptoms of dementia of the Alzheimer type. Our initial attempts to synthesize (‐)Huperzine A resulted in the racemic mixture of (−)Huperzine A. We have therefore compared the in vitro and in vivo effects of (±)Huperzine A with those of (−)Huperzine A in rats. The results indicate a similar biological mechanism of action between the two, but that the racemic mixture of (±) Huperzine A has a weaker biological activity than the natural product (−)Huperzine A, presumably due to the presence in the mixture of (+)Huperzine A, which is considerably less potent than the (−)isomer.

Original language	English (US)
Pages (from-to)	304-306
Number of pages	3
Journal	Annals of the New York Academy of Sciences
Volume	695
Issue number	1
DOIs	https://doi.org/10.1111/j.1749-6632.1993.tb23071.x
State	Published - Sep 1993
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1111/j.1749-6632.1993.tb23071.x

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title = "Natural and Synthetic Huperzine A: Effect on Cholinergic Function in Vitro and in Vivo",

abstract = "Huperzine A has been shown to be useful in the treatment of symptoms of dementia of the Alzheimer type. Our initial attempts to synthesize (‐)Huperzine A resulted in the racemic mixture of (−)Huperzine A. We have therefore compared the in vitro and in vivo effects of (±)Huperzine A with those of (−)Huperzine A in rats. The results indicate a similar biological mechanism of action between the two, but that the racemic mixture of (±) Huperzine A has a weaker biological activity than the natural product (−)Huperzine A, presumably due to the presence in the mixture of (+)Huperzine A, which is considerably less potent than the (−)isomer.",

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T1 - Natural and Synthetic Huperzine A

T2 - Effect on Cholinergic Function in Vitro and in Vivo

AU - HANIN, ISRAEL

AU - TANG, XI‐CAN ‐C

AU - KINDEL, GISELA L.

AU - KOZIKOWSKI, ALAN P.

PY - 1993/9

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N2 - Huperzine A has been shown to be useful in the treatment of symptoms of dementia of the Alzheimer type. Our initial attempts to synthesize (‐)Huperzine A resulted in the racemic mixture of (−)Huperzine A. We have therefore compared the in vitro and in vivo effects of (±)Huperzine A with those of (−)Huperzine A in rats. The results indicate a similar biological mechanism of action between the two, but that the racemic mixture of (±) Huperzine A has a weaker biological activity than the natural product (−)Huperzine A, presumably due to the presence in the mixture of (+)Huperzine A, which is considerably less potent than the (−)isomer.

AB - Huperzine A has been shown to be useful in the treatment of symptoms of dementia of the Alzheimer type. Our initial attempts to synthesize (‐)Huperzine A resulted in the racemic mixture of (−)Huperzine A. We have therefore compared the in vitro and in vivo effects of (±)Huperzine A with those of (−)Huperzine A in rats. The results indicate a similar biological mechanism of action between the two, but that the racemic mixture of (±) Huperzine A has a weaker biological activity than the natural product (−)Huperzine A, presumably due to the presence in the mixture of (+)Huperzine A, which is considerably less potent than the (−)isomer.

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Natural and Synthetic Huperzine A: Effect on Cholinergic Function in Vitro and in Vivo

Abstract

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