Nationwide Inpatient Prevalence, Predictors, and Outcomes of Alzheimer's Disease among Older Adults in the United States, 2002-2012

May A. Beydoun, Hind A. Beydoun, Alyssa A. Gamaldo, Ola S. Rostant, Greg A. Dore, Alan B. Zonderman, Shaker M Eid

Research output: Contribution to journalArticle

Abstract

In the inpatient setting, prevalence, predictors, and outcomes [mortality risk (MR), length of stay (LOS), and total charges (TC)] of Alzheimer's disease (AD) are largely unknown. We used data on older adults (60+ y) from the Nationwide Inpatient Sample (NIS) 2002-2012. AD prevalence was ∼3.12% in 2012 (total weighted discharges with AD±standard error: 474, 410±6,276). Co-morbidities prevailing more in AD inpatient admissions included depression (OR = 1.67, 95% CI: 1.63-1.71, p <0.001), fluid/electrolyte disorders (OR = 1.25, 95% CI: 1.22-1.27, p <0.001), weight loss (OR = 1.26, 95% CI: 1.22-1.30, p <0.001), and psychosis (OR = 2.59, 95% CI: 2.47-2.71, p <0.001), with mean total co-morbidities increasing over time. AD was linked to higherMRand longer LOS, but lower TC. TC rose in AD, while MR and LOS dropped markedly over time. In AD, co-morbidities predicting simultaneously higher MR, TC, and LOS (2012) included congestive heart failure, chronic pulmonary disease, coagulopathy, fluid/electrolyte disorders, metastatic cancer, paralysis, pulmonary circulatory disorders, and weight loss. In sum, co-morbidities and TC increased over time in AD, whileMRand LOS dropped. Fewco-morbidities predicted occurrence of AD or adverse outcomes in AD.

Original languageEnglish (US)
Pages (from-to)361-375
Number of pages15
JournalJournal of Alzheimer's Disease
Volume48
Issue number2
DOIs
StatePublished - Sep 9 2015

Fingerprint

Inpatients
Alzheimer Disease
Length of Stay
Morbidity
Electrolytes
Mortality
Weight Loss
Paralysis
Psychotic Disorders
Lung Diseases
Lung Neoplasms
Chronic Disease
Heart Failure
Depression

Keywords

  • Alzheimer's disease
  • co-morbidity
  • health care cost
  • inpatient sample
  • length of stay
  • mortality
  • older adults

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Nationwide Inpatient Prevalence, Predictors, and Outcomes of Alzheimer's Disease among Older Adults in the United States, 2002-2012. / Beydoun, May A.; Beydoun, Hind A.; Gamaldo, Alyssa A.; Rostant, Ola S.; Dore, Greg A.; Zonderman, Alan B.; Eid, Shaker M.

In: Journal of Alzheimer's Disease, Vol. 48, No. 2, 09.09.2015, p. 361-375.

Research output: Contribution to journalArticle

Beydoun, May A. ; Beydoun, Hind A. ; Gamaldo, Alyssa A. ; Rostant, Ola S. ; Dore, Greg A. ; Zonderman, Alan B. ; Eid, Shaker M. / Nationwide Inpatient Prevalence, Predictors, and Outcomes of Alzheimer's Disease among Older Adults in the United States, 2002-2012. In: Journal of Alzheimer's Disease. 2015 ; Vol. 48, No. 2. pp. 361-375.
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abstract = "In the inpatient setting, prevalence, predictors, and outcomes [mortality risk (MR), length of stay (LOS), and total charges (TC)] of Alzheimer's disease (AD) are largely unknown. We used data on older adults (60+ y) from the Nationwide Inpatient Sample (NIS) 2002-2012. AD prevalence was ∼3.12{\%} in 2012 (total weighted discharges with AD±standard error: 474, 410±6,276). Co-morbidities prevailing more in AD inpatient admissions included depression (OR = 1.67, 95{\%} CI: 1.63-1.71, p <0.001), fluid/electrolyte disorders (OR = 1.25, 95{\%} CI: 1.22-1.27, p <0.001), weight loss (OR = 1.26, 95{\%} CI: 1.22-1.30, p <0.001), and psychosis (OR = 2.59, 95{\%} CI: 2.47-2.71, p <0.001), with mean total co-morbidities increasing over time. AD was linked to higherMRand longer LOS, but lower TC. TC rose in AD, while MR and LOS dropped markedly over time. In AD, co-morbidities predicting simultaneously higher MR, TC, and LOS (2012) included congestive heart failure, chronic pulmonary disease, coagulopathy, fluid/electrolyte disorders, metastatic cancer, paralysis, pulmonary circulatory disorders, and weight loss. In sum, co-morbidities and TC increased over time in AD, whileMRand LOS dropped. Fewco-morbidities predicted occurrence of AD or adverse outcomes in AD.",
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AU - Rostant, Ola S.

AU - Dore, Greg A.

AU - Zonderman, Alan B.

AU - Eid, Shaker M

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