National trends in hydroxyurea and opioid prescribing for sickle cell disease by office-based physicians in the United States, 1997-2017

Zhuo Tony Su, Jodi Segal, Sophie Lanzkron, Foluso Joy Ogunsile

Research output: Contribution to journalArticle

Abstract

Purpose: To identify trends in physician drug prescribing practices for sickle cell disease (SCD). Methods: We used data from the National Disease and Therapeutic Index to evaluate medications prescribed to children (definition: aged 19 years or younger) and adults (20 years or older) with SCD by office-based physicians in the United States during 1997 to 2017. Prescriptions were evaluated in 3-year intervals. Results: The proportion of SCD visits that included new/continued hydroxyurea prescriptions increased from less than or equal to 8% before 2009 to 33% in 2015 to 2017. The increase was significant in visits by children (2.5% in 1997-1999 to 47% in 2015-2017; P =.003 by Spearman's rank-order correlation) but not in adults (6.9% to 11%; P =.12). Opioids, started/continued in 13% (lowest 3-year average) to 35% (highest) of visits by children and 55% to 81% of visits by adults, remained the most frequently prescribed medications for SCD overall. There were no significant changes over time in opioid prescribing for adults (P =.64) or children (P =.38). Hematologists/oncologists accounted for a higher proportion of visits by children (67.2% over 1997-2017) than adults (25.2%), while emergency medicine visits were higher in adults (14.0%) than children (2.6%). Conclusions: This study suggests a robust increase in hydroxyurea prescribing for children with SCD. The BABY HUG trial, which demonstrated safety and efficacy of starting hydroxyurea in infancy and informed current SCD guidelines recommending broader use in children, may have contributed to this increase. However, hydroxyurea prescribing for adults remains infrequent and considerably lower than opioids. Barriers in access to specialist care persist for adults with SCD.

Original languageEnglish (US)
JournalPharmacoepidemiology and Drug Safety
DOIs
StatePublished - Jan 1 2019

Fingerprint

Physicians' Offices
Hydroxyurea
Sickle Cell Anemia
Opioid Analgesics
Prescriptions
Drug Prescriptions
Emergency Medicine
Young Adult
Guidelines
Physicians
Safety

Keywords

  • health care disparities
  • hydroxyurea
  • opioid
  • pharmacoepidemiology
  • prescribing patterns
  • sickle cell disease

ASJC Scopus subject areas

  • Epidemiology
  • Pharmacology (medical)

Cite this

@article{e776add1b1cf438782b45640befdff2b,
title = "National trends in hydroxyurea and opioid prescribing for sickle cell disease by office-based physicians in the United States, 1997-2017",
abstract = "Purpose: To identify trends in physician drug prescribing practices for sickle cell disease (SCD). Methods: We used data from the National Disease and Therapeutic Index to evaluate medications prescribed to children (definition: aged 19 years or younger) and adults (20 years or older) with SCD by office-based physicians in the United States during 1997 to 2017. Prescriptions were evaluated in 3-year intervals. Results: The proportion of SCD visits that included new/continued hydroxyurea prescriptions increased from less than or equal to 8{\%} before 2009 to 33{\%} in 2015 to 2017. The increase was significant in visits by children (2.5{\%} in 1997-1999 to 47{\%} in 2015-2017; P =.003 by Spearman's rank-order correlation) but not in adults (6.9{\%} to 11{\%}; P =.12). Opioids, started/continued in 13{\%} (lowest 3-year average) to 35{\%} (highest) of visits by children and 55{\%} to 81{\%} of visits by adults, remained the most frequently prescribed medications for SCD overall. There were no significant changes over time in opioid prescribing for adults (P =.64) or children (P =.38). Hematologists/oncologists accounted for a higher proportion of visits by children (67.2{\%} over 1997-2017) than adults (25.2{\%}), while emergency medicine visits were higher in adults (14.0{\%}) than children (2.6{\%}). Conclusions: This study suggests a robust increase in hydroxyurea prescribing for children with SCD. The BABY HUG trial, which demonstrated safety and efficacy of starting hydroxyurea in infancy and informed current SCD guidelines recommending broader use in children, may have contributed to this increase. However, hydroxyurea prescribing for adults remains infrequent and considerably lower than opioids. Barriers in access to specialist care persist for adults with SCD.",
keywords = "health care disparities, hydroxyurea, opioid, pharmacoepidemiology, prescribing patterns, sickle cell disease",
author = "Su, {Zhuo Tony} and Jodi Segal and Sophie Lanzkron and Ogunsile, {Foluso Joy}",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/pds.4860",
language = "English (US)",
journal = "Pharmacoepidemiology and Drug Safety",
issn = "1053-8569",
publisher = "John Wiley and Sons Ltd",

}

TY - JOUR

T1 - National trends in hydroxyurea and opioid prescribing for sickle cell disease by office-based physicians in the United States, 1997-2017

AU - Su, Zhuo Tony

AU - Segal, Jodi

AU - Lanzkron, Sophie

AU - Ogunsile, Foluso Joy

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: To identify trends in physician drug prescribing practices for sickle cell disease (SCD). Methods: We used data from the National Disease and Therapeutic Index to evaluate medications prescribed to children (definition: aged 19 years or younger) and adults (20 years or older) with SCD by office-based physicians in the United States during 1997 to 2017. Prescriptions were evaluated in 3-year intervals. Results: The proportion of SCD visits that included new/continued hydroxyurea prescriptions increased from less than or equal to 8% before 2009 to 33% in 2015 to 2017. The increase was significant in visits by children (2.5% in 1997-1999 to 47% in 2015-2017; P =.003 by Spearman's rank-order correlation) but not in adults (6.9% to 11%; P =.12). Opioids, started/continued in 13% (lowest 3-year average) to 35% (highest) of visits by children and 55% to 81% of visits by adults, remained the most frequently prescribed medications for SCD overall. There were no significant changes over time in opioid prescribing for adults (P =.64) or children (P =.38). Hematologists/oncologists accounted for a higher proportion of visits by children (67.2% over 1997-2017) than adults (25.2%), while emergency medicine visits were higher in adults (14.0%) than children (2.6%). Conclusions: This study suggests a robust increase in hydroxyurea prescribing for children with SCD. The BABY HUG trial, which demonstrated safety and efficacy of starting hydroxyurea in infancy and informed current SCD guidelines recommending broader use in children, may have contributed to this increase. However, hydroxyurea prescribing for adults remains infrequent and considerably lower than opioids. Barriers in access to specialist care persist for adults with SCD.

AB - Purpose: To identify trends in physician drug prescribing practices for sickle cell disease (SCD). Methods: We used data from the National Disease and Therapeutic Index to evaluate medications prescribed to children (definition: aged 19 years or younger) and adults (20 years or older) with SCD by office-based physicians in the United States during 1997 to 2017. Prescriptions were evaluated in 3-year intervals. Results: The proportion of SCD visits that included new/continued hydroxyurea prescriptions increased from less than or equal to 8% before 2009 to 33% in 2015 to 2017. The increase was significant in visits by children (2.5% in 1997-1999 to 47% in 2015-2017; P =.003 by Spearman's rank-order correlation) but not in adults (6.9% to 11%; P =.12). Opioids, started/continued in 13% (lowest 3-year average) to 35% (highest) of visits by children and 55% to 81% of visits by adults, remained the most frequently prescribed medications for SCD overall. There were no significant changes over time in opioid prescribing for adults (P =.64) or children (P =.38). Hematologists/oncologists accounted for a higher proportion of visits by children (67.2% over 1997-2017) than adults (25.2%), while emergency medicine visits were higher in adults (14.0%) than children (2.6%). Conclusions: This study suggests a robust increase in hydroxyurea prescribing for children with SCD. The BABY HUG trial, which demonstrated safety and efficacy of starting hydroxyurea in infancy and informed current SCD guidelines recommending broader use in children, may have contributed to this increase. However, hydroxyurea prescribing for adults remains infrequent and considerably lower than opioids. Barriers in access to specialist care persist for adults with SCD.

KW - health care disparities

KW - hydroxyurea

KW - opioid

KW - pharmacoepidemiology

KW - prescribing patterns

KW - sickle cell disease

UR - http://www.scopus.com/inward/record.url?scp=85069728309&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069728309&partnerID=8YFLogxK

U2 - 10.1002/pds.4860

DO - 10.1002/pds.4860

M3 - Article

C2 - 31328369

AN - SCOPUS:85069728309

JO - Pharmacoepidemiology and Drug Safety

JF - Pharmacoepidemiology and Drug Safety

SN - 1053-8569

ER -