National Surveillance of Antimicrobial Resistance in Neisseria gonorrhoeae

The Gonococcal Isolate Surveillance Project

Research output: Contribution to journalArticle

Abstract

The Gonococcal Isolate Surveillance Project is a national sentinel surveillance system to estimate levels and monitor trends of antimicrobial resistance in prospectively collected isolates of Neisseria gonorrhoeae. Of 6204 isolates evaluated from 21 clinic sites between September 1987 and December 1988, 21% met at least one of the surveillance criteria for resistance to penicillin, tetracycline, cefoxitin, or spectinomycin; 2.2% were penicillinase-producing N gonorrhoeae; 1.0% had high-level plasmid-mediated tetracycline resistance; and 16.8% of the isolates without plasmid-mediated resistance had chromosomally mediated resistance (defined as a minimum inhibitory concentration ≥2 μg/mL) to penicillin, tetracycline, or cefoxitin. Three isolates were resistant to spectinomycin. All isolates were susceptible to ceftriaxone. Resistant isolates were identified from all participating centers. Patient demographic and behavioral characteristics were not predictive of infections caused by resistant organisms. These results demonstrate the wide distribution of antimicrobial-resistant N gonorrhoeae and support recent changes in Centers for Disease Control therapy recommendations for gonococcal infections that no longer recommend tetracycline and penicillin as first-line therapies.

Original languageEnglish (US)
Pages (from-to)1413-1417
Number of pages5
JournalJournal of the American Medical Association
Volume264
Issue number11
DOIs
StatePublished - Sep 19 1990

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Neisseria gonorrhoeae
Tetracycline
Spectinomycin
Cefoxitin
Gonorrhea
Penicillins
Plasmids
Sentinel Surveillance
Penicillin Resistance
Penicillinase
Tetracycline Resistance
Ceftriaxone
Microbial Sensitivity Tests
Centers for Disease Control and Prevention (U.S.)
Infection
Demography
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

National Surveillance of Antimicrobial Resistance in Neisseria gonorrhoeae. / The Gonococcal Isolate Surveillance Project.

In: Journal of the American Medical Association, Vol. 264, No. 11, 19.09.1990, p. 1413-1417.

Research output: Contribution to journalArticle

The Gonococcal Isolate Surveillance Project. / National Surveillance of Antimicrobial Resistance in Neisseria gonorrhoeae. In: Journal of the American Medical Association. 1990 ; Vol. 264, No. 11. pp. 1413-1417.
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