Objectives: To describe the vision-targeted, healthrelated quality of life, measured with the National Eye Institute Visual Function Questionnaire (NEI-VFQ), in patients with age-related macular degeneration, cataract, or reduced visual acuity; to determine the relationship between the NEI-VFQ subscale scores and clinical measures of visual function; and to assess the internal consistency and reliability of the NEI-VFQ subscales. Design: The 39-item NEI-VFQ was administered at the 5-year clinic visit to 4077 Age-Related Eye Disease Study participants. Results: The subscales of the NEI-VFQ had moderate to high internal consistency (Cronbach's α = 0.58-0.91). The NEI-VFQ scores for participants with advanced age-related macular degeneration in 1 or both eyes, severe nuclear opacity, reduced visual acuity, or cataract surgery generally were lower than scores for disease-free participants (P<.001). Conclusion: These findings support the use of the NEI-VFQ as a measure of vision- targeted, health-related quality of life among patients with age-related macular degeneration, cataract, or reduced visual acuity.
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