National Cancer Institute Workshop on Proton Therapy for Children: Considerations Regarding Brainstem Injury

Daphne Haas-Kogan, Daniel Indelicato, Harald Paganetti, Natia Esiashvili, Anita Mahajan, Torunn Yock, Stella Flampouri, Shannon MacDonald, Maryam Fouladi, Kry Stephen, John Kalapurakal, Stephanie A Terezakis, Hanne Kooy, David Grosshans, Mike Makrigiorgos, Kavita Mishra, Tina Young Poussaint, Kenneth J Cohen, Thomas Fitzgerald, Vinai GondiArthur Liu, Jeff Michalski, Dragan Mirkovic, Radhe Mohan, Stephanie Perkins, Kenneth Wong, Bhadrasain Vikram, Jeff Buchsbaum, Larry Kun

Research output: Contribution to journalReview article

Abstract

Purpose: Proton therapy can allow for superior avoidance of normal tissues. A widespread consensus has been reached that proton therapy should be used for patients with curable pediatric brain tumor to avoid critical central nervous system structures. Brainstem necrosis is a potentially devastating, but rare, complication of radiation. Recent reports of brainstem necrosis after proton therapy have raised concerns over the potential biological differences among radiation modalities. We have summarized findings from the National Cancer Institute Workshop on Proton Therapy for Children convened in May 2016 to examine brainstem injury. Methods and Materials: Twenty-seven physicians, physicists, and researchers from 17 institutions with expertise met to discuss this issue. The definition of brainstem injury, imaging of this entity, clinical experience with photons and photons, and potential biological differences among these radiation modalities were thoroughly discussed and reviewed. The 3 largest US pediatric proton therapy centers collectively summarized the incidence of symptomatic brainstem injury and physics details (planning, dosimetry, delivery) for 671 children with focal posterior fossa tumors treated with protons from 2006 to 2016. Results: The average rate of symptomatic brainstem toxicity from the 3 largest US pediatric proton centers was 2.38%. The actuarial rate of grade ≥2 brainstem toxicity was successfully reduced from 12.7% to 0% at 1 center after adopting modified radiation guidelines. Guidelines for treatment planning and current consensus brainstem constraints for proton therapy are presented. The current knowledge regarding linear energy transfer (LET) and its relationship to relative biological effectiveness (RBE) are defined. We review the current state of LET-based planning. Conclusions: Brainstem injury is a rare complication of radiation therapy for both photons and protons. Substantial dosimetric data have been collected for brainstem injury after proton therapy, and established guidelines to allow for safe delivery of proton radiation have been defined. Increased capability exists to incorporate LET optimization; however, further research is needed to fully explore the capabilities of LET- and RBE-based planning.

Original languageEnglish (US)
Pages (from-to)152-168
Number of pages17
JournalInternational Journal of Radiation Oncology Biology Physics
Volume101
Issue number1
DOIs
StatePublished - May 1 2018

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Proton Therapy
National Cancer Institute (U.S.)
Brain Stem
therapy
cancer
Education
protons
Wounds and Injuries
Linear Energy Transfer
linear energy transfer (LET)
Radiation
Protons
planning
Photons
Relative Biological Effectiveness
radiation
Guidelines
necrosis
Pediatrics
toxicity

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

National Cancer Institute Workshop on Proton Therapy for Children : Considerations Regarding Brainstem Injury. / Haas-Kogan, Daphne; Indelicato, Daniel; Paganetti, Harald; Esiashvili, Natia; Mahajan, Anita; Yock, Torunn; Flampouri, Stella; MacDonald, Shannon; Fouladi, Maryam; Stephen, Kry; Kalapurakal, John; Terezakis, Stephanie A; Kooy, Hanne; Grosshans, David; Makrigiorgos, Mike; Mishra, Kavita; Poussaint, Tina Young; Cohen, Kenneth J; Fitzgerald, Thomas; Gondi, Vinai; Liu, Arthur; Michalski, Jeff; Mirkovic, Dragan; Mohan, Radhe; Perkins, Stephanie; Wong, Kenneth; Vikram, Bhadrasain; Buchsbaum, Jeff; Kun, Larry.

In: International Journal of Radiation Oncology Biology Physics, Vol. 101, No. 1, 01.05.2018, p. 152-168.

Research output: Contribution to journalReview article

Haas-Kogan, D, Indelicato, D, Paganetti, H, Esiashvili, N, Mahajan, A, Yock, T, Flampouri, S, MacDonald, S, Fouladi, M, Stephen, K, Kalapurakal, J, Terezakis, SA, Kooy, H, Grosshans, D, Makrigiorgos, M, Mishra, K, Poussaint, TY, Cohen, KJ, Fitzgerald, T, Gondi, V, Liu, A, Michalski, J, Mirkovic, D, Mohan, R, Perkins, S, Wong, K, Vikram, B, Buchsbaum, J & Kun, L 2018, 'National Cancer Institute Workshop on Proton Therapy for Children: Considerations Regarding Brainstem Injury', International Journal of Radiation Oncology Biology Physics, vol. 101, no. 1, pp. 152-168. https://doi.org/10.1016/j.ijrobp.2018.01.013
Haas-Kogan, Daphne ; Indelicato, Daniel ; Paganetti, Harald ; Esiashvili, Natia ; Mahajan, Anita ; Yock, Torunn ; Flampouri, Stella ; MacDonald, Shannon ; Fouladi, Maryam ; Stephen, Kry ; Kalapurakal, John ; Terezakis, Stephanie A ; Kooy, Hanne ; Grosshans, David ; Makrigiorgos, Mike ; Mishra, Kavita ; Poussaint, Tina Young ; Cohen, Kenneth J ; Fitzgerald, Thomas ; Gondi, Vinai ; Liu, Arthur ; Michalski, Jeff ; Mirkovic, Dragan ; Mohan, Radhe ; Perkins, Stephanie ; Wong, Kenneth ; Vikram, Bhadrasain ; Buchsbaum, Jeff ; Kun, Larry. / National Cancer Institute Workshop on Proton Therapy for Children : Considerations Regarding Brainstem Injury. In: International Journal of Radiation Oncology Biology Physics. 2018 ; Vol. 101, No. 1. pp. 152-168.
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AU - Haas-Kogan, Daphne

AU - Indelicato, Daniel

AU - Paganetti, Harald

AU - Esiashvili, Natia

AU - Mahajan, Anita

AU - Yock, Torunn

AU - Flampouri, Stella

AU - MacDonald, Shannon

AU - Fouladi, Maryam

AU - Stephen, Kry

AU - Kalapurakal, John

AU - Terezakis, Stephanie A

AU - Kooy, Hanne

AU - Grosshans, David

AU - Makrigiorgos, Mike

AU - Mishra, Kavita

AU - Poussaint, Tina Young

AU - Cohen, Kenneth J

AU - Fitzgerald, Thomas

AU - Gondi, Vinai

AU - Liu, Arthur

AU - Michalski, Jeff

AU - Mirkovic, Dragan

AU - Mohan, Radhe

AU - Perkins, Stephanie

AU - Wong, Kenneth

AU - Vikram, Bhadrasain

AU - Buchsbaum, Jeff

AU - Kun, Larry

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