Na+ regulates release of Ca++ sequestered in synaptosomal mitochondria

Research output: Contribution to journalArticle

Abstract

The interactions of Na+ and Ca++ were examined in synaptosomes and mitochondria. Na+ decreased both 45Ca++ binding to synaptosomes and loss of 45Ca++ from mitochondria. The ability of low concentrations of a local anesthetic, N,N-diethylamino-octyl 3,4,5-trimethoxybenzoate, to inhibit movement of Ca from intracellular bound stores was found to be associated with increased uptake of Ca by synaptosomes. A Na+-dependent regulatory effect was postulated between mitochondrial binding of Ca and influx of Ca into the nerve terminal. In addition, the results suggest difficulties in distinguishing between Na+-dependent and Ca++-dependent processes in synaptosomal function.

Original languageEnglish (US)
Pages (from-to)464-469
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume77
Issue number2
DOIs
StatePublished - Jul 25 1977
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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