Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement

A. G. Togias, R. M. Naclerio, D. Proud, J. E. Fish, N Franklin Adkinson, A. Kagey-Sobotka, Philip S. Norman, L. M. Lichtenstein

Research output: Contribution to journalArticle

Abstract

The purpose of our study was to assess the effect of cold, dry air (CDA) on the nasal mucosa of selected individuals in relation to the release of inflammatory mediators associated with mast cells. 12 subjects with a history of nasal symptoms of rhinorrhea and congestion upon cold or dry environmental exposure were challenged by nasal breathing of CDA and warm, moist air (WMA). Each subject was tested on two occasions with the order of the challenges reversed. Symptom scores were recorded, and the levels of histamine, prostaglandin (PG) D2, kinins, and [3H]N-α-tosyl-L-arginine methyl ester (TAME)-esterase activity in nasal lavage fluids were measured. CDA caused a significant increase in mediator levels and in symptom scores as compared to baseline or to WMA. No significant increase in symptom scores or mediators was noted after WMA challenge, with the exception of a marginal increase in kinins. The response to CDA was similar, regardless of challenge order. Changes in mediators correlated with one another, and symptom scores correlated significantly with the levels of histamine, kinins, and PGD2. Five subjects without a history of nasal symptoms on cold air exposure had no change in mediators or symptom scores after CDA or WMA challenge. We conclude that CDA causes the release of inflammatory mediators possibly associated with mast cells and speculate that such a mechanism may be involved in the bronchospasm induced by CDA in asthmatics.

Original languageEnglish (US)
Pages (from-to)1375-1381
Number of pages7
JournalJournal of Clinical Investigation
Volume76
Issue number4
StatePublished - 1985
Externally publishedYes

Fingerprint

Nose
Mast Cells
Air
Kinins
Prostaglandin D2
Histamine
Nasal Lavage Fluid
Bronchial Spasm
Nasal Mucosa
Environmental Exposure
Respiration

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Togias, A. G., Naclerio, R. M., Proud, D., Fish, J. E., Adkinson, N. F., Kagey-Sobotka, A., ... Lichtenstein, L. M. (1985). Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement. Journal of Clinical Investigation, 76(4), 1375-1381.

Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement. / Togias, A. G.; Naclerio, R. M.; Proud, D.; Fish, J. E.; Adkinson, N Franklin; Kagey-Sobotka, A.; Norman, Philip S.; Lichtenstein, L. M.

In: Journal of Clinical Investigation, Vol. 76, No. 4, 1985, p. 1375-1381.

Research output: Contribution to journalArticle

Togias, AG, Naclerio, RM, Proud, D, Fish, JE, Adkinson, NF, Kagey-Sobotka, A, Norman, PS & Lichtenstein, LM 1985, 'Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement', Journal of Clinical Investigation, vol. 76, no. 4, pp. 1375-1381.
Togias, A. G. ; Naclerio, R. M. ; Proud, D. ; Fish, J. E. ; Adkinson, N Franklin ; Kagey-Sobotka, A. ; Norman, Philip S. ; Lichtenstein, L. M. / Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement. In: Journal of Clinical Investigation. 1985 ; Vol. 76, No. 4. pp. 1375-1381.
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