Narp knockout mice show normal reactivity to novelty but attenuated recovery from neophobia

Ashley M. Blouin, Jong Ah J. Lee, Bo Tao, Dani R. Smith, Alexander W. Johnson, Jay M. Baraban, Irving M. Reti

Research output: Contribution to journalArticle

Abstract

Narp knockout (KO) mice demonstrate cognitive inflexibility and addictive behavior, which are associated with abnormal reactivity to a novel stimulus. To assess reactivity to novelty, we tested Narp KO and wild-type (WT) mice on a neophobia procedure. Both Narp KO and WT mice showed a similar decrease in consumption upon initial exposure to a novel flavor, but Narp KO mice did not increase consumption with subsequent exposures to the novel flavor like the WT mice. Therefore, Narp KO mice do not have abnormal reactivity to novelty but show deficits in adapting behavior to reflect the updated value of a stimulus.

Original languageEnglish (US)
Pages (from-to)178-181
Number of pages4
JournalBehavioural Brain Research
Volume257
DOIs
StatePublished - Nov 15 2013

Keywords

  • Addiction
  • Extinction
  • Narp
  • Neophobia
  • Novelty
  • Recovery from neophobia

ASJC Scopus subject areas

  • Behavioral Neuroscience

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