Narp deletion blocks extinction of morphine place preference conditioning

Hans S. Crombag, Mercy Dickson, Megan Dinenna, Alexander W. Johnson, Mark S. Perin, Peter C. Holland, Jay M. Baraban, Irving M. Reti

Research output: Contribution to journalArticlepeer-review

Abstract

As drug abuse can be viewed as a maladaptive form of neuronal plasticity, attention has focused on defining the synaptic plasticity mechanisms that mediate the long-term effects of these drugs. As Narp is secreted at synaptic sites and binds to the extracellular surface of AMPA receptors, it has been implicated in mediating enduring forms of synaptic plasticity. Accordingly, to assess its potential role in the long-lasting behavioral effects of drugs of abuse, we have investigated the impact of Narp deletion on sustained behavioral responses elicited by repeated morphine administration. Narp knockout mice display normal locomotor sensitization and conditioned place preference, but are markedly resistant to extinction of place preference. Thus, these findings indicate that Narp plays a selective role in extinction, possibly by its effects on AMPA receptor trafficking.

Original languageEnglish (US)
Pages (from-to)857-866
Number of pages10
JournalNeuropsychopharmacology
Volume34
Issue number4
DOIs
StatePublished - Mar 2009

Keywords

  • Glutamate
  • Knockout mice
  • Neuronal activity-regulated pentraxin
  • Orexin
  • Place preference conditioning
  • Psychomotor sensitization

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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