TY - JOUR
T1 - Nanotechnology approaches for ocular drug delivery
AU - Xu, Qingguo
AU - Kambhampati, Siva P.
AU - Kannan, Rangaramanujam M.
PY - 2013/1
Y1 - 2013/1
N2 - Blindness is a major health concern worldwide that has a powerful impact on afflicted individuals and their families, and is associated with enormous socio-economical consequences. The Middle East is heavily impacted by blindness, and the problem there is augmented by an increasing incidence of diabetes in the population. An appropriate drug/gene delivery system that can sustain and deliver therapeutics to the target tissues and cells is a key need for ocular therapies. The application of nanotechnology in medicine is undergoing rapid progress, and the recent developments in nanomedicine-based therapeutic approaches may bring significant benefits to address the leading causes of blindness associated with cataract, glaucoma, diabetic retinopathy and retinal degeneration. In this brief review, we highlight some promising nanomedicine-based therapeutic approaches for drug and gene delivery to the anterior and posterior segments.
AB - Blindness is a major health concern worldwide that has a powerful impact on afflicted individuals and their families, and is associated with enormous socio-economical consequences. The Middle East is heavily impacted by blindness, and the problem there is augmented by an increasing incidence of diabetes in the population. An appropriate drug/gene delivery system that can sustain and deliver therapeutics to the target tissues and cells is a key need for ocular therapies. The application of nanotechnology in medicine is undergoing rapid progress, and the recent developments in nanomedicine-based therapeutic approaches may bring significant benefits to address the leading causes of blindness associated with cataract, glaucoma, diabetic retinopathy and retinal degeneration. In this brief review, we highlight some promising nanomedicine-based therapeutic approaches for drug and gene delivery to the anterior and posterior segments.
KW - Age-Related Macular Degeneration
KW - Dendrimers
KW - Nanoparticles
KW - Ocular Gene Therapy
KW - Targeted Therapies
UR - http://www.scopus.com/inward/record.url?scp=84878785223&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878785223&partnerID=8YFLogxK
U2 - 10.4103/0974-9233.106384
DO - 10.4103/0974-9233.106384
M3 - Article
C2 - 23580849
AN - SCOPUS:84878785223
SN - 0974-9233
VL - 20
SP - 26
EP - 37
JO - Middle East African Journal of Ophthalmology
JF - Middle East African Journal of Ophthalmology
IS - 1
ER -