Nanostructure, effective properties, and deformation pattern of the cochlear outer hair cell cytoskeleton

Alexander A. Spector, Mohammed Ameen, Panos G. Charalambides, Aleksander S Popel

Research output: Contribution to journalArticle

Abstract

We consider the mechanical properties of the outer hair cell cytoskeleton. The cytoskeleton is represented as a set of microdomains of different sizes and orientations composed of actin filaments and spectrin crosslinks. An intermediate material between domains is also introduced. The domain characteristics are randomly generated and the histograms of the cytoskeleton stiffness moduli are obtained. We solve an inverse problem and estimate the stiffness of the crosslink and connective molecule in the intermediate material. We discovered a pattern of highly inhomogeneous deformation of the cytoskeleton where the circumferential strain is primarily determined by the deformation of the intermediate material.

Original languageEnglish (US)
Pages (from-to)180-187
Number of pages8
JournalJournal of Biomechanical Engineering
Volume124
Issue number2
DOIs
StatePublished - 2002

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Outer Auditory Hair Cells
Nanostructures
Cytoskeleton
Cells
Stiffness
Inverse problems
Spectrin
Actin Cytoskeleton
Mechanical properties
Molecules

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biophysics

Cite this

Nanostructure, effective properties, and deformation pattern of the cochlear outer hair cell cytoskeleton. / Spector, Alexander A.; Ameen, Mohammed; Charalambides, Panos G.; Popel, Aleksander S.

In: Journal of Biomechanical Engineering, Vol. 124, No. 2, 2002, p. 180-187.

Research output: Contribution to journalArticle

Spector, Alexander A. ; Ameen, Mohammed ; Charalambides, Panos G. ; Popel, Aleksander S. / Nanostructure, effective properties, and deformation pattern of the cochlear outer hair cell cytoskeleton. In: Journal of Biomechanical Engineering. 2002 ; Vol. 124, No. 2. pp. 180-187.
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