Nanoscale complexity of phospholipid monolayers investigated by near-field scanning optical microscopy

Jeeseong Hwang, Lukas K. Tamm, Christine Böhm, Tirunelveli S. Ramalingam, Eric Betzig, Michael Edidin

Research output: Contribution to journalArticlepeer-review

Abstract

Near-field scanning optical microscopy of phospholipid monolayers doped with fluorescent lipid analogs reveals previously undescribed features in various phases, including a concentration gradient at the liquid-expanded/ liquid-condensed domain boundary and weblike structures in the solid-condensed phase. Presumably, the web structures are grain boundaries between crystalline solid lipid. These structures are strongly modulated by the addition of low concentrations of cholesterol and ganglioside GM1 in the monolayer.

Original languageEnglish (US)
Pages (from-to)610-614
Number of pages5
JournalScience
Volume270
Issue number5236
DOIs
StatePublished - 1995

ASJC Scopus subject areas

  • General

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