Nanophthalmic sclera. Morphologic and tissue culture studies

B. Y J T Yue, J. Duvall, Morton F Goldberg, A. Puck, Mark O M Tso, J. Sugar

Research output: Contribution to journalArticle

Abstract

We performed morphologic and tissue culture studies on scleral tissues observed from a nanophthalmic patient. Seen by light electron microscopy, collagens in these unusually thick scleral tissues were arranged in irregularly interfacing bundles. The size of the collagen fibers was more variable than that observed in the controls. These abnormal fibers appeared twisted and, in some areas, were more closely packed. In tissue culture, scleral cells derived from the nanophthalmic patient synthesized proteins and collagen at a rate similar to that of normal control cells. The level of glycosaminoglycan produced, however, was markedly reduced. The modified glycosaminoglycan metabolism in scleral cells may be related to the abnormal packing of collagen bundles, which may in turn contribute to the thickening of sclera and the formation of nanophthalmos.

Original languageEnglish (US)
Pages (from-to)534-541
Number of pages8
JournalOphthalmology
Volume93
Issue number4
StatePublished - 1986

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Sclera
Collagen
Glycosaminoglycans
Electron Microscopy
Light
Proteins

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Yue, B. Y. J. T., Duvall, J., Goldberg, M. F., Puck, A., Tso, M. O. M., & Sugar, J. (1986). Nanophthalmic sclera. Morphologic and tissue culture studies. Ophthalmology, 93(4), 534-541.

Nanophthalmic sclera. Morphologic and tissue culture studies. / Yue, B. Y J T; Duvall, J.; Goldberg, Morton F; Puck, A.; Tso, Mark O M; Sugar, J.

In: Ophthalmology, Vol. 93, No. 4, 1986, p. 534-541.

Research output: Contribution to journalArticle

Yue, BYJT, Duvall, J, Goldberg, MF, Puck, A, Tso, MOM & Sugar, J 1986, 'Nanophthalmic sclera. Morphologic and tissue culture studies', Ophthalmology, vol. 93, no. 4, pp. 534-541.
Yue, B. Y J T ; Duvall, J. ; Goldberg, Morton F ; Puck, A. ; Tso, Mark O M ; Sugar, J. / Nanophthalmic sclera. Morphologic and tissue culture studies. In: Ophthalmology. 1986 ; Vol. 93, No. 4. pp. 534-541.
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