Nanophthalmic sclera: Fibronectin studies

B. Y J T Yue, A. Kurosawa, J. Duvall, M. F. Goldberg, M. O M Tso, J. Sugar

Research output: Contribution to journalArticle

Abstract

The authors performed fibronectin studies on scleral specimens derived from a patient with nanophthalmos. Immunohistochemical staining with antifibronectin was conducted using both formaldehyde-fixed, paraffin-embedded tissue sections and unfixed tissue-culture scleral cells. In each case, the nanophthalmic samples exhibited fibronectin staining stronger than that obtained from normal human subjects. Results from an enzyme-linked immunosorbent assay (ELISA) confirmed the histologic findings that, in tissue culture, the patient's scleral cells contained and secreted a higher amount of fibronectin than did the normal control cells. The elevated fibronectin level may be related to the development of nanophthalmos.

Original languageEnglish (US)
Pages (from-to)56-60
Number of pages5
JournalOphthalmology
Volume95
Issue number1
StatePublished - 1988
Externally publishedYes

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Sclera
Fibronectins
Staining and Labeling
Paraffin
Formaldehyde
Cell Culture Techniques
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Yue, B. Y. J. T., Kurosawa, A., Duvall, J., Goldberg, M. F., Tso, M. O. M., & Sugar, J. (1988). Nanophthalmic sclera: Fibronectin studies. Ophthalmology, 95(1), 56-60.

Nanophthalmic sclera : Fibronectin studies. / Yue, B. Y J T; Kurosawa, A.; Duvall, J.; Goldberg, M. F.; Tso, M. O M; Sugar, J.

In: Ophthalmology, Vol. 95, No. 1, 1988, p. 56-60.

Research output: Contribution to journalArticle

Yue, BYJT, Kurosawa, A, Duvall, J, Goldberg, MF, Tso, MOM & Sugar, J 1988, 'Nanophthalmic sclera: Fibronectin studies', Ophthalmology, vol. 95, no. 1, pp. 56-60.
Yue BYJT, Kurosawa A, Duvall J, Goldberg MF, Tso MOM, Sugar J. Nanophthalmic sclera: Fibronectin studies. Ophthalmology. 1988;95(1):56-60.
Yue, B. Y J T ; Kurosawa, A. ; Duvall, J. ; Goldberg, M. F. ; Tso, M. O M ; Sugar, J. / Nanophthalmic sclera : Fibronectin studies. In: Ophthalmology. 1988 ; Vol. 95, No. 1. pp. 56-60.
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