Nanoparticle-induced intraperitoneal hyperthermia and targeted photoablation in treating ovarian cancer

Chao Chih Wu, Yuh Cheng Yang, Yun Ting Hsu, T. C. Wu, Chien Fu Hung, Jung Tang Huang, Chih Long Chang

Research output: Contribution to journalArticle

Abstract

Hyperthermic intraperitoneal chemotherapy is effective in treating various intraabdominal malignancies. However, this therapeutic modality can only be performed during surgical operations and cannot be used repeatedly. We propose repeatedly noninvasive hyperthermia mediated by pegylated silica-core gold nanoshells (pSGNs) in vivo with external near-infrared (NIR) laser irradiation. This study demonstrated that repeated photothermal treatment can effectively eliminate intraperitoneal tumors in mouse ovarian cancer models without damage of normal tissues. By conjugating pSGNs with anti-human CD47 monoclonal antibody, a significant photoablative effect can be achieved using lower amount of pSGNs and shorter NIR laser irradiation. Conjugated pSGNs specifically targeted and bound to cancer cells inside the peritoneal cavity. Our results indicate the possibility of a noninvasive method of repeated hyperthermia and photoablative therapies using nanoparticles. This has substantial clinical potential in treating ovarian and other intraperitoneal cancers.

Original languageEnglish (US)
Pages (from-to)26861-26875
Number of pages15
JournalOncotarget
Volume6
Issue number29
DOIs
StatePublished - Jan 1 2015

Keywords

  • Gold nanoshells
  • Hypethermia
  • Ovarian cancer

ASJC Scopus subject areas

  • Oncology

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