Nanoparticle-based theranostic agents

Jin Xie, Seulki Lee, Xiaoyuan Chen

Research output: Contribution to journalReview article

Abstract

Theranostic nanomedicine is emerging as a promising therapeutic paradigm. It takes advantage of the high capacity of nanoplatforms to ferry cargo and loads onto them both imaging and therapeutic functions. The resulting nanosystems, capable of diagnosis, drug delivery and monitoring of therapeutic response, are expected to play a significant role in the dawning era of personalized medicine, and much research effort has been devoted toward that goal. A convenience in constructing such function-integrated agents is that many nanoplatforms are already, themselves, imaging agents. Their well-developed surface chemistry makes it easy to load them with pharmaceutics and promote them to be theranostic nanosystems. Iron oxide nanoparticles, quantum dots, carbon nanotubes, gold nanoparticles and silica nanoparticles, have been previously well investigated in the imaging setting and are candidate nanoplatforms for building up nanoparticle-based theranostics. In the current article, we will outline the progress along this line, organized by the category of the core materials. We will focus on construction strategies and will discuss the challenges and opportunities associated with this emerging technology.

Original languageEnglish (US)
Pages (from-to)1064-1079
Number of pages16
JournalAdvanced Drug Delivery Reviews
Volume62
Issue number11
DOIs
StatePublished - Aug 30 2010
Externally publishedYes

Keywords

  • Carbon nanotubes
  • Drug delivery
  • Gene delivery
  • Gold nanoparticles
  • Iron oxide nanoparticles
  • Molecular imaging
  • Nanomedicine
  • Quantum dots
  • Silica nanoparticles
  • Theranostics

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Nanoparticle-based theranostic agents'. Together they form a unique fingerprint.

  • Cite this