Nanocaged platforms: Modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger

Parham Sahandi Zangabad, Mahdi Karimi, Fatemeh Mehdizadeh, Hedieh Malekzad, Alireza Ghasemi, Sajad Bahrami, Hossein Zare, Mohsen Moghoofei, Amin Hekmatmanesh, Michael R. Hamblin

Research output: Contribution to journalReview article

Abstract

Nanocages (NCs) have emerged as a new class of drug-carriers, with a wide range of possibilities in multi-modality medical treatments and theranostics. Nanocages can overcome such limitations as high toxicity caused by anti-cancer chemotherapy or by the nanocarrier itself, due to their unique characteristics. These properties consist of: (1) a high loading-capacity (spacious interior); (2) a porous structure (analogous to openings between the bars of the cage); (3) enabling smart release (a key to unlock the cage); and (4) a low likelihood of unfavorable immune responses (the outside of the cage is safe). In this review, we cover different classes of NC structures such as virus-like particles (VLPs), protein NCs, DNA NCs, supramolecular nanosystems, hybrid metal-organic NCs, gold NCs, carbon-based NCs and silica NCs. Moreover, NC-assisted drug delivery including modification methods, drug immobilization, active targeting, and stimulus-responsive release mechanisms are discussed, highlighting the advantages, disadvantages and challenges. Finally, translation of NCs into clinical applications, and an up-to-date assessment of the nanotoxicology considerations of NCs are presented.

Original languageEnglish (US)
Pages (from-to)1356-1392
Number of pages37
JournalNanoscale
Volume9
Issue number4
DOIs
StatePublished - Jan 28 2017
Externally publishedYes

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Nanosystems
Drug Carriers
Chemotherapy
Drug delivery
Viruses
Silicon Dioxide
Gold
Toxicity
DNA
Carbon
Metals
Silica
Proteins
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Sahandi Zangabad, P., Karimi, M., Mehdizadeh, F., Malekzad, H., Ghasemi, A., Bahrami, S., ... Hamblin, M. R. (2017). Nanocaged platforms: Modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger. Nanoscale, 9(4), 1356-1392. https://doi.org/10.1039/c6nr07315h

Nanocaged platforms : Modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger. / Sahandi Zangabad, Parham; Karimi, Mahdi; Mehdizadeh, Fatemeh; Malekzad, Hedieh; Ghasemi, Alireza; Bahrami, Sajad; Zare, Hossein; Moghoofei, Mohsen; Hekmatmanesh, Amin; Hamblin, Michael R.

In: Nanoscale, Vol. 9, No. 4, 28.01.2017, p. 1356-1392.

Research output: Contribution to journalReview article

Sahandi Zangabad, P, Karimi, M, Mehdizadeh, F, Malekzad, H, Ghasemi, A, Bahrami, S, Zare, H, Moghoofei, M, Hekmatmanesh, A & Hamblin, MR 2017, 'Nanocaged platforms: Modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger', Nanoscale, vol. 9, no. 4, pp. 1356-1392. https://doi.org/10.1039/c6nr07315h
Sahandi Zangabad P, Karimi M, Mehdizadeh F, Malekzad H, Ghasemi A, Bahrami S et al. Nanocaged platforms: Modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger. Nanoscale. 2017 Jan 28;9(4):1356-1392. https://doi.org/10.1039/c6nr07315h
Sahandi Zangabad, Parham ; Karimi, Mahdi ; Mehdizadeh, Fatemeh ; Malekzad, Hedieh ; Ghasemi, Alireza ; Bahrami, Sajad ; Zare, Hossein ; Moghoofei, Mohsen ; Hekmatmanesh, Amin ; Hamblin, Michael R. / Nanocaged platforms : Modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger. In: Nanoscale. 2017 ; Vol. 9, No. 4. pp. 1356-1392.
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