Naloxone increases pain induced by topical capsaicin in healthy human volunteers

William S Anderson, Rishi N. Sheth, Badreddine Bencherif, James J. Frost, James N Campbell

Research output: Contribution to journalArticle

Abstract

Opioid receptors occur in locations of strategic importance within the central nervous system for modulation of pain. Is pain reduced by ongoing inhibition mediated by activation of these receptors? Experiments to date in which the opioid-receptor antagonist, naloxone, is administered during a painful event have yielded unclear results. Topically applied capsaicin can be used to induce tonic pain of moderate to severe intensity without tissue injury and is an ideal stimulus for studying acute pain modulation. We therefore conducted a placebo-controlled double-blind crossover study to investigate the effects of naloxone on capsaicin-induced pain (five men, four women, aged 29±5 years). Capsaicin (10%) was applied topically and subjects rated pain every 2min. The subjects were told that any drug given to them could increase, decrease, or not change their pain sensation. Pain plateaued after 20min. At 26min subjects received either naloxone or placebo in double-blind fashion. At 56min subjects received the alternative (placebo or naloxone). In a second session the order of presentation was reversed. The naloxone induced a significant increase in pain compared both to baseline (P

Original languageEnglish (US)
Pages (from-to)207-216
Number of pages10
JournalPain
Volume99
Issue number1-2
DOIs
StatePublished - Sep 2002

Fingerprint

Capsaicin
Naloxone
Healthy Volunteers
Pain
Placebos
Narcotic Antagonists
Acute Pain
Opioid Receptors
Double-Blind Method
Cross-Over Studies
Central Nervous System
Wounds and Injuries
Pharmaceutical Preparations

Keywords

  • Analgesia
  • Hyperalgesia
  • Magnitude estimation scale
  • Opioid-receptor
  • Psychophysics
  • Randomized clinical trial

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Neuroscience(all)
  • Pharmacology
  • Clinical Psychology

Cite this

Naloxone increases pain induced by topical capsaicin in healthy human volunteers. / Anderson, William S; Sheth, Rishi N.; Bencherif, Badreddine; Frost, James J.; Campbell, James N.

In: Pain, Vol. 99, No. 1-2, 09.2002, p. 207-216.

Research output: Contribution to journalArticle

Anderson, William S ; Sheth, Rishi N. ; Bencherif, Badreddine ; Frost, James J. ; Campbell, James N. / Naloxone increases pain induced by topical capsaicin in healthy human volunteers. In: Pain. 2002 ; Vol. 99, No. 1-2. pp. 207-216.
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