TY - JOUR
T1 - Naloxone enhancement of memory processes
T2 - Effects of other opiate antagonists
AU - Gallagher, Michela
N1 - Funding Information:
~ Supported by NIMH Grant MH35554 and NIMH Research Scientist Development Award K02 MH00406 to M. G. Send reprint requests to Michela Gallagher, Department of Psychology, Davie Hall 013A, University of North Carolina, Chapel Hill, N.C. 27514.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1982/8
Y1 - 1982/8
N2 - Previous research has demonstrated that naloxone, an opiate antagonist, facilitates time-dependent memory processes. The present study was undertaken to determine whether the effect of naloxone on memory processes is shared by other opiate antagonists and whether this effect exhibits stereospecificity. The opiate antagonists used included naloxone, naltrexone, deprenorphine, and levallorphan. In addition, stereospecificity was evaluated by the use of dextrallorphan. The results demonstrate that increased retention of passive avoidance conditioning in rats is produced by posttraining administration of each of the opiate antagonists employed in this investigation. In addition, the effect of theopiate antagonist levallorphan was demonstrated to be stereospecific because dextrallorphan did not significantly alter retention. This experiment provides strong support for the interpretation that naloxone facilitates retention of passive avoidance conditioning as a function of its opiate antagonist properties.
AB - Previous research has demonstrated that naloxone, an opiate antagonist, facilitates time-dependent memory processes. The present study was undertaken to determine whether the effect of naloxone on memory processes is shared by other opiate antagonists and whether this effect exhibits stereospecificity. The opiate antagonists used included naloxone, naltrexone, deprenorphine, and levallorphan. In addition, stereospecificity was evaluated by the use of dextrallorphan. The results demonstrate that increased retention of passive avoidance conditioning in rats is produced by posttraining administration of each of the opiate antagonists employed in this investigation. In addition, the effect of theopiate antagonist levallorphan was demonstrated to be stereospecific because dextrallorphan did not significantly alter retention. This experiment provides strong support for the interpretation that naloxone facilitates retention of passive avoidance conditioning as a function of its opiate antagonist properties.
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U2 - 10.1016/S0163-1047(82)91020-2
DO - 10.1016/S0163-1047(82)91020-2
M3 - Article
C2 - 6299265
AN - SCOPUS:0020364451
SN - 0163-1047
VL - 35
SP - 375
EP - 382
JO - Behavioral and Neural Biology
JF - Behavioral and Neural Biology
IS - 4
ER -